research Integrative Proteo-Transcriptomic Characterization of Androgenetic Alopecia Identifying ME1-Mediated PPAR Signaling as a Potential Mediator
ME1 and PPAR signaling may influence hair loss in androgenetic alopecia.
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5 / 722 results research 3D Bioprinting of Engineered Exosomes Secreted from M2-Polarized Macrophages Through Immunomodulatory Biomaterial Promotes In Vivo Wound Healing and Angiogenesis
This study developed bifunctional hydrogel inks to promote M2 macrophage polarization and exosome cultivation for wound healing. The researchers created polyamine-modified 3D printable hydrogels to enhance M2-exosome secretion, which were then encapsulated in a biocompatible collagen/decellularized extracellular matrix bioink. The 3D-printed hydrogels promoted M2 macrophage polarization through JAK/STAT and PPAR signaling pathways and facilitated M2-Exo secretion. The bioink was biocompatible with skin cells and, when co-cultured with various cell types, upregulated skin-associated biomarkers and downregulated the MAPK signaling pathway. In a subcutaneous wound model, the hydrogel demonstrated effective wound remodeling and hair follicle induction while reducing pro-inflammatory activation, suggesting its potential as a therapeutic strategy for skin disorders.
research Proteomics Reveals the Role of PLIN2 in Regulating the Secondary Hair Follicle Cycle in Cashmere Goats
PLIN2 affects hair growth in cashmere goats, potentially improving cashmere quality.
research Adipose Transcriptome in the Scalp of Androgenetic Alopecia
The scalp fat tissue of men with hair loss shows changes in gene activity that may contribute to their condition.
research Integration Analysis of Transcriptome and Proteome Reveals the Mechanisms of Goat Wool Bending
The research identified key proteins and genes that may influence wool bending in goats.
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community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment
The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.
community Is there a topical androgen receptor blocker so we don't have to fuck with the enzyme and destroy our allopregnanolone, but go and hit the end target straight?
The conversation discusses topical androgen receptor blockers for hair loss, mentioning Clascoterone, Pyrilutamide, GT20029, and RU58841. Ketoconazole's effectiveness and application methods are also debated.
community A concise, easy-to-understand post on Androgenic Alopecia theory and its practical applications
The mechanism of Androgenic Alopecia and practical applications of treatments like Minoxidil, Finasteride, RU58841, dermarolling, scalp massages, anti-fungals, progesterone, estrogen, PPAR-γ activators, reducing oxidative stress, and scalp exercises. It explains why DHT is important in AA and how other factors might be involved such as hypoxia, increased DKK-1 expression, morphological changes to the scalp, skull growth during childhood/puberty, and blood flow.
community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied
Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.
community Interesting article links major MPB theories to western diet (and life-style)
Poor diet and lifestyle contribute to male pattern baldness. Treatments like Minoxidil, dietary changes, and lifestyle adjustments may help slow hair loss.