Integrative Proteo-Transcriptomic Characterization of Androgenetic Alopecia Identifying ME1-Mediated PPAR Signaling as a Potential Mediator

This study provides an integrative proteo-transcriptomic analysis of androgenetic alopecia (AGA) by examining bald and haired scalp biopsies from 4 male patients. The research identifies 2565 differentially expressed genes and 315 differentially expressed proteins, highlighting the significant role of PPAR signaling in AGA pathogenesis. ME1, a key regulator in this pathway, is implicated in lipid metabolism, suggesting its potential influence on hair growth. Despite the small sample size limiting definitive conclusions, the study offers valuable insights into the molecular mechanisms of AGA, emphasizing the need for further research with larger cohorts.