Risk Factors and Lipid Metabolism Characteristics of Early-Onset Male Androgenetic Alopecia: A Pilot Study

May 2024 in “ Journal of cosmetic dermatology ”

Shuqin Wang, Shuyun Xu, Sui Wang, Wenhao Fang, Wanrong Shi

androgenetic alopecia HDL-C 25-hydroxyvitamin D metabolic syndrome ceramides sphingomyelins Cer(d38:5) TG(15:0/18:1/18:1) testosterone HDL cholesterol vitamin D

TLDR Low HDL-C, uric acid, and 25-hydroxyvitamin D are risk factors for early-onset male hair loss.

This pilot study compared 40 patients with early-onset male androgenetic alopecia (MAA) to 45 healthy controls, finding that MAA patients had significantly lower levels of HDL-C, uric acid, and 25-hydroxyvitamin D, and a higher prevalence of metabolic syndrome (37.5% vs. 17.78%). Abnormal lipid metabolism was noted, with decreased ceramides and sphingomyelins, and Cer(d38:5) and TG(15:0/18:1/18:1) identified as potential biomarkers. No significant differences were found in total testosterone levels. The study suggests lipid metabolism alterations and low HDL-C and 25(OH)D levels may be linked to early-onset MAA, highlighting the need for further research.

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