Risk Factors and Lipid Metabolism Characteristics of Early-Onset Male Androgenetic Alopecia: A Pilot Study

    Shuqin Wang, Shuyun Xu, Sui Wang, Wenhao Fang, Wanrong Shi
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    TLDR Low HDL-C, uric acid, and 25-hydroxyvitamin D are risk factors for early-onset male hair loss.
    This pilot study investigated the risk factors and metabolic characteristics of early-onset male androgenetic alopecia (MAA) by comparing 40 MAA patients with 45 healthy controls. It found that 37.50% of MAA patients had metabolic syndrome, significantly higher than the 17.78% in the control group. MAA patients exhibited lower levels of HDL-C, uric acid, and 25-hydroxyvitamin D compared to controls, while total testosterone levels showed no significant difference. Lipid profiling revealed that early-onset MAA patients had significantly lower levels of ceramide and sphingomyelin, suggesting these lipids may act as protective factors. The study concludes that low HDL-C, uric acid, and 25-hydroxyvitamin D are independent risk factors for early-onset MAA, and abnormal lipid metabolism is a characteristic of the condition.
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