Risk Factors and Lipid Metabolism Characteristics of Early-Onset Male Androgenetic Alopecia: A Pilot Study

This pilot study compared 40 patients with early-onset male androgenetic alopecia (MAA) to 45 healthy controls, finding that MAA patients had significantly lower levels of HDL-C, uric acid, and 25-hydroxyvitamin D, and a higher prevalence of metabolic syndrome (37.5% vs. 17.78%). Abnormal lipid metabolism was noted, with decreased ceramides and sphingomyelins, and Cer(d38:5) and TG(15:0/18:1/18:1) identified as potential biomarkers. No significant differences were found in total testosterone levels. The study suggests lipid metabolism alterations and low HDL-C and 25(OH)D levels may be linked to early-onset MAA, highlighting the need for further research.