Proteomics Reveals the Role of PLIN2 in Regulating the Secondary Hair Follicle Cycle in Cashmere Goats

    Cuiling Wu, Qiumin Lu, Shengchao Ma, Nuramina Mamat, Sen Tang, Wenna Liu, Yaqian Wang, Asma Anwar, Yingjie Lu, Qiang‐Qiang Ma, Gulinigaer Aimaier, Xuefeng Fu
    TLDR PLIN2 affects hair growth in cashmere goats, potentially improving cashmere quality.
    The study explores the role of the PLIN2 gene in regulating the secondary hair follicle cycle in Jiangnan cashmere goats through proteomic analysis. Researchers identified differentially expressed proteins (DEPs) across various hair follicle stages, highlighting key pathways such as the PPAR signaling pathway and cytoskeletal organization. PLIN2 was found to significantly impact dermal papilla cell (DPC) proliferation and apoptosis, with its knockdown promoting cell growth and inhibiting apoptosis. The study involved 5 female goats and confirmed findings through Western blot analysis. These insights into PLIN2's role in hair follicle development could inform strategies to enhance cashmere yield and quality.
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