Structural Behavior of Keratin-Associated Protein 8.1 in Human Hair as Revealed by a Monoclonal Antibody

    August 2018 in “ Journal of Structural Biology ”
    Hiroki Akiba, Emina Ikeuchi, Javkhlan Ganbat, Hiroki Fujikawa, Osamu Arai-Kusano, Hiroko Iwanari, Makoto Nakakido, Takao Hamakubo, Yutaka Shimomura, Kouhei Tsumoto
    TLDR KAP8.1 protein is crucial for hair structure and interacts with keratin 85.
    The study focused on the keratin-associated protein 8.1 (KAP8.1) in human hair, revealing its significant role in hair structure formation. Researchers developed a monoclonal antibody, E4304, which specifically interacted with KAP8.1 in both native and denatured states, allowing for detailed analysis of its distribution in hair tissue. The findings showed that the distribution of KAP8.1 protein mirrored that of its mRNA, supporting its fundamental role in the keratinizing zone of the hair shaft cortex. This research provided insights into the interaction of KAP8.1 with keratin 85 (K85), contributing to the understanding of hair structure and potential treatments for hair-related conditions.
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