The Susceptibility of Disulfide Bonds to Modification in Keratin Fibers Undergoing Tensile Stress

    April 2022 in “ Biophysical Journal ”
    Duane P. Harland, C. Popescu, Marina Richena … Jeffrey E. Plowman
    Studysummary In this study, certain cysteine residues in Romney sheep wool fibers were labeled more often during stretching tests, particularly under wet conditions, suggesting variability in their disulfide bond contributions to fiber mechanics depending on hydration.
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    Research cited in this study 17

    1. A Detailed Mapping of the Readily Accessible Disulfide Bonds in the Cortex of Wool Fibers Proteins · 2021
    2. Understanding Curly Hair Mechanics: Fiber Strength ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2019
    3. Wanted, Dead and Alive: Why a Multidisciplinary Approach Is Needed to Unlock Hair Treatment Potential Experimental Dermatology · 2019
    4. Development of Hair Fibers Advances in experimental medicine and biology · 2018
    5. Macrofibril Formation Advances in experimental medicine and biology · 2018
    6. The Structure of the Amorphous Matrix of Keratins Journal of structural biology · 2017
    7. Keratin Network Modifications Lead to the Mechanical Stiffening of the Hair Follicle Fiber Proceedings of the National Academy of Sciences of the United States of America · 2016
    8. Mapping the Accessibility of the Disulfide Crosslink Network in the Wool Fiber Cortex Proteins Structure Function and Bioinformatics · 2014
    9. Three-Dimensional Architecture of Macrofibrils in the Human Scalp Hair Cortex Journal of Structural Biology · 2014
    10. Expression Patterns of Keratin Intermediate Filament and Keratin Associated Protein Genes in Wool Follicles Differentiation · 2009
    11. Identification of Reptilian Genes Encoding Hair Keratin-Like Proteins Suggests a New Scenario for the Evolutionary Origin of Hair Proceedings of the National Academy of Sciences · 2008
    12. Healthy Hair: What Is It? ˜The œjournal of investigative dermatology. Symposium proceedings/˜The œJournal of investigative dermatology symposium proceedings · 2007
    13. Keratins of the Human Hair Follicle International review of cytology · 2005
    14. Characterization of a First Domain of Human High Glycine-Tyrosine and High Sulfur Keratin-Associated Protein Genes on Chromosome 21q22.1 Journal of biological chemistry/˜The œJournal of biological chemistry · 2002
    15. The Catalog of Human Hair Keratins Journal of Biological Chemistry · 2001
    16. In Vitro Assembly and Structure of Trichocyte Keratin Intermediate Filaments ˜The œjournal of cell biology/˜The œJournal of cell biology · 2000
    17. The Catalog of Human Hair Keratins Journal of biological chemistry/˜The œJournal of biological chemistry · 1999

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    1. Crosslinking Between Trichocyte Keratins and Keratin Associated Proteins Advances in experimental medicine and biology · 2018