Parental Uveitis Causes Elevated Hair Loss in Offspring of C57BL/6J Mice

March 2022 in “ Experimental Eye Research ”

Jianping Liu, Guangnian Yin, Kaijiao Hu, Hui Huang, Fei Xu, Yaying Yang, Feilan Chen

hair loss differentially expressed genes skin development PPAR signaling pathway hair follicle development melanin granules

Studysummary This study suggests that in a moderately susceptible mouse population, parental uveitis affects the skin development and alters gene expression profiles related to various pathways in offspring without increasing susceptibility to autoimmune uveitis. Our plain-language summary of this paper — not a Tressless recommendation.

The study investigated the impact of parental uveitis on offspring in C57BL/6J mice, revealing that parental uveitis led to hair loss in the offspring. The research identified differentially expressed genes (DEGs) in the skin and eyes of the offspring, which were enriched in pathways related to skin development, nervous system development, and the PPAR signaling pathway. These findings provided molecular evidence for the influence of parental uveitis on offspring development, highlighting changes in hair follicle development and melanin granules in the skin. The study did not find increased susceptibility to experimental autoimmune uveitis (EAU) in the offspring at a low-dose induction.

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