Case Series: Gene Expression Analysis in Canine Vogt-Koyanagi-Harada/Uveodermatologic Syndrome and Vitiligo Reveals Conserved Immunopathogenesis Pathways Between Dog and Human Autoimmune Pigmentary Disorders
December 2020
in “
Frontiers in Immunology
”
Vogt-Koyanagi-Harada syndrome vitiligo autoimmune pigmentary disorders T cell gene signatures IFNG TNF PRF1 IL15 CTSW CXCL10 CCL5 FOXP3 TBX21 IGFBP5 FOXO1 PECAM1 TGFB3 SFRP2 CXCL7 VKH T cells interferon gamma tumor necrosis factor perforin interleukin 15 cathepsin W C-X-C motif chemokine ligand 10 C-C motif chemokine ligand 5 forkhead box P3 T-box transcription factor TBX21 insulin-like growth factor-binding protein 5 forkhead box O1 platelet endothelial cell adhesion molecule transforming growth factor beta 3 secreted frizzled-related protein 2 C-X-C motif chemokine ligand 7
Studysummary This study found that certain T cell-associated genes were upregulated in dogs with Vogt-Koyanagi-Harada syndrome and vitiligo, suggesting a shared immunopathogenesis with humans.
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