research FOXO1, TGF-β Regulation and Wound Healing
This study found that the transcription factor FOXO1 plays a crucial role in wound healing by protecting keratinocytes from oxidative stress and regulating TGF-β expression.
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5 / 998 results research The Nude Mutant Gene Foxn1 Is a HOXC13 Regulatory Target during Hair Follicle and Nail Differentiation
This study suggests a regulatory model where HOXC13 activates Foxn1, affecting hair and nail differentiation, supported by similarities in Hoxc13(tm1Mrc) and Foxn1(nu) mice phenotypes and gene expression patterns.
research Human ClinicalPhenotype Associated with FOXN1 Mutations
This review discusses the human Nude/SCID phenotype and FOXN1 gene's role in immunological disorders affecting T-cell development but reports no new clinical findings.
research Foxn1 in Skin Development, Homeostasis and Wound Healing
This review focuses on the role of the transcription factor Foxn1 in skin biology and discusses its potential implications for regenerative medicine, but reports no new clinical results.
research Suppression of FOXO1 activity by SIRT1-mediated deacetylation weakening the intratumoral androgen autocrine function in glioblastoma
This study found that elevated androgens in the brains of glioblastoma patients are produced by tumor cells, and overexpressing Sirt1 reduces these levels, thereby delaying tumor progression more effectively than conventional therapy in mouse models.
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