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GlossarySecreted Frizzled-Related Protein 2 (SFRP2)

regulates cell signaling pathways affecting hair follicle development

Secreted Frizzled-Related Protein 2 (SFRP2) is a protein that plays a role in regulating cell signaling pathways, particularly the Wnt signaling pathway, which is crucial for cell growth, differentiation, and development. In the context of hair biology, SFRP2 can influence hair follicle development and cycling, potentially impacting conditions like alopecia.

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research SFRP2/DPP4 and FMO1/LSP1 Define Major Fibroblast Populations in Human Skin

225 citations, April 2018 in “Journal of Investigative Dermatology”

Two main types of fibroblasts with unique functions and additional subtypes were identified in human skin.

research MiR-218-5p Regulates Skin and Hair Follicle Development Through Wnt/β-Catenin Signaling Pathway by Targeting SFRP2

54 citations, April 2019 in “Journal of cellular physiology”

miR-218-5p helps skin and hair growth by targeting SFRP2 and activating a specific signaling pathway.

research SFRP2 Augments Wnt/β-Catenin Signalling in Cultured Dermal Papilla Cells

17 citations, February 2016 in “Experimental Dermatology”

SFRP2 boosts Wnt3a/β-catenin signals in hair growth cells, with stronger effects in beard cells than scalp cells.

research The Role of Dexamethasone in Mediating the Contradictory Effects of Wnt Antagonists SFRP2 and SFRP3 on Human Hair Follicle Growth

October 2023 in “Scientific reports”

Dexamethasone affects hair growth by altering levels of proteins that either promote or inhibit hair follicle growth.

research The Expression Rules of Wnt10b and SFRP2 Genes in the Skin of Wanxi Angora Rabbits

January 2013

Wnt10b promotes hair growth, while SFRP2 inhibits it in Wanxi Angora rabbits.

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community find a cure for this shit already

in Chat 207 upvotes 4 years ago

Treatments used to prevent and treat male pattern baldness, the difficulty in finding a permanent cure for hair loss, and the potential financial motivations of companies not wanting to find a cure.