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GlossaryTransforming Growth Factor Beta (TGFB)

protein regulating cell growth, differentiation, and immune responses

Transforming Growth Factor Beta (TGF-β) is a protein that plays a crucial role in regulating cell growth, differentiation, and immune responses. It is involved in various biological processes, including wound healing and the development of fibrosis, and can influence hair growth by affecting the hair follicle cycle.

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research Case Series: Gene Expression Analysis in Canine Vogt-Koyanagi-Harada/Uveodermatologic Syndrome and Vitiligo Reveals Conserved Immunopathogenesis Pathways Between Dog and Human Autoimmune Pigmentary Disorders

20 citations , December 2020 in “Frontiers in Immunology”

The immune processes causing VKH and vitiligo are similar in dogs and humans.

research Calreticulin: Non-Endoplasmic Reticulum Functions in Physiology and Disease

341 citations , November 2009 in “The FASEB Journal”

Calreticulin has roles in healing, immune response, and disease beyond its known functions in the endoplasmic reticulum.

research The Hair Follicle as an Estrogen Target and Source

159 citations , July 2006 in “Endocrine Reviews”

Estrogens significantly influence hair growth by interacting with receptors in hair follicles and may help regulate the hair growth cycle.

research TGF-β Family Signaling in Stem Cells

132 citations , August 2012 in “Biochimica et Biophysica Acta (BBA) - General Subjects”

TGF-β signaling is crucial for stem cell maintenance, differentiation, and has implications for cancer treatment.

research Macrophages Regulate Schwann Cell Maturation After Nerve Injury

130 citations , September 2018 in “Cell Reports”

Macrophages help heal nerves by aiding the maturation of Schwann cells and are important for nerve repair.

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community Microneedling-induced shedding after 5 months?

in Progress Pictures 22 upvotes 1 month ago

A user experienced significant hair loss after starting microneedling, despite using dutasteride and topical minoxidil. They are advised to consult a doctor as the shedding pattern is unusual and may indicate alopecia areata or other scalp conditions.

community Group Buy for MR antagonist finerenone

in Product 11 upvotes 2 years ago

User discusses group buy for finerenone, a third-gen mineralocorticoid antagonist for hair loss treatment. Finerenone inhibits TGFb, NOX, and ROS, and improves renal and cardiac function; topical dose should be no more than 10mg per day.

community My Theory Of Androgenic Alopecia

in Research/Science 17 upvotes 3 weeks ago

Hair loss is linked to cellular physiology and the IGF-1 to TGF-B1 ratio, not just androgen sensitivity. The theory lacks evidence, while finasteride and minoxidil are effective treatments.

community Had anyone used peptides for help with regrowth?

in Treatment 7 upvotes 4 months ago

Peptides like GHK-Cu are discussed for hair regrowth, with mixed results; some users report no regrowth, while others notice thicker hair. Topical application is common, and proper sourcing and mixing are emphasized.

community Hairloss - what hormones to check?

in Finasteride/Dutasteride 11 upvotes 1 year ago

The user is concerned about hair loss despite using oral finasteride, oral minoxidil, and topical minoxidil. They are seeking advice on additional blood tests to identify potential causes.

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