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Glossary Transforming Growth Factor Beta 3

regulates cell growth and tissue repair, affecting hair follicles

Transforming Growth Factor Beta 3 (TGF-β3) is a protein that plays a crucial role in regulating cell growth, differentiation, and tissue repair. It is particularly important in wound healing and the development of the skin and hair follicles, making it a significant factor in studies related to alopecia and other hair growth disorders.

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Research

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research trans-3,4'-Dimethyl-3-hydroxyflavanone, a Hair Growth Enhancing Active Component, Decreases Active Transforming Growth Factor .BETA.2 (TGF-.BETA.2) through Control of Urokinase-Type Plasminogen Activator (uPA) on the Surface of Keratinocytes

10 citations , January 2008 in “Biological and Pharmaceutical Bulletin”

This study found that trans-3,4'-Dimethyl-3-hydroxyflavanone reduces active TGF-beta2 levels in human keratinocytes, suggesting it may enhance hair growth by suppressing the TGF-beta2 activation pathway.

research P311 induces the transdifferentiation of epidermal stem cells to myofibroblast-like cells by stimulating transforming growth factor β1 expression

24 citations , December 2016 in “Stem Cell Research & Therapy”

This study found that P311 triggers transdifferentiation of epidermal stem cells into myofibroblast-like cells via TGFβ1/Smad signaling during wound healing.

research BI02 (P97): Epidermal growth factor receptor inhibitor therapy induces a distinct inflammatory hair follicle response that includes a collapse of immune privilege

July 2022 in “British Journal of Dermatology”

This study found that epidermal growth factor receptor inhibitors used in cancer treatment induce a distinct inflammatory response in hair follicles, marked by immune privilege collapse and upregulation of inflammatory pathways.

research Perbandingan Kadar Transforming Growth Factor-Beta 1 pada Platelet Rich Plasma dengan Metode Pure dan Buffy Coat pada Populasi Individu Sehat

August 2025 in “Intisari Sains Medis”

This study found that in healthy individuals, TGF-β1 levels in platelet-rich plasma are significantly higher when extracted using the buffy coat method compared to the pure method, with additional gender differences observed only in the buffy coat PRP.

research Faculty Opinions recommendation of Expression of truncated latent TGF-beta-binding protein modulates TGF-beta signaling.

May 2005 in “Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature”

In this study, transgenic mice with a truncated latent transforming growth factor-beta-binding protein showed reduced keratinocyte proliferation and alterations in the hair cycle due to mis-localization of transforming growth factor-beta.

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Community Join

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community Taurine supplements work for hair growth?

9 upvotes 2 years ago

The conversation discusses taurine supplements for hair growth, highlighting their potential to reduce DHT and improve hair health. A user comments that people often try alternatives to finasteride.

community A new study by Deng and colleagues set out to explore differences between balding and non balding scalps...

39 upvotes 4 years ago

Balding scalps have more androgen receptors, leading to increased TGF-beta, which causes blood vessel loss and hair follicle miniaturization. Blocking androgen signaling and TGF-beta may help prevent hair loss.

community Why do we have head hair in first place if we evolved to start losing it in some cases as soon as puberty hits

140 upvotes 11 months ago

Hair loss is influenced by genetics and sensitivity to hormones like DHT. Treatments like Minoxidil and finasteride are commonly used, and baldness persists as it doesn't affect reproductive success.

community Microneedling-induced shedding after 5 months?

in Progress Pictures 22 upvotes 10 months ago

A user experienced significant hair loss after starting microneedling, despite using dutasteride and topical minoxidil. They are advised to consult a doctor as the shedding pattern is unusual and may indicate alopecia areata or other scalp conditions.

community Holding out for a miracle drug

59 upvotes 4 months ago

A 41-year-old male has been using a combination of treatments for hair regrowth, including finasteride, minoxidil, a laser cap, ketoconazole shampoo, and rosemary oil, with some progress noted. He is maintaining his current regimen in hopes of a future miracle drug while considering hair transplants and other treatments like dutasteride and copper peptides.

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Learn

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learn Epidermal Growth Factor

learn Vascular Endothelial Growth Factor

learn Platelet-Rich Plasma

What is platelet-derived growth factor beta polypeptide (PDGF-BB), and does it stimulate new hair growth? PDGF-BB is a growth factor that signals to dermal papilla cells and promotes blood-vessel formation; mouse studies report it can push follicles into the growth phase, and human evidence comes only indirectly from PRP trials. No PDGF product is approved for hair restoration and there is no published human trial of PDGF-BB on its own.

learn Thymosin Beta 4

How is Thymosin Beta 4 typically incorporated into experimental or advanced hair growth products? Thymosin Beta 4 is not an ingredient in any approved hair-loss product; it is an unapproved research peptide sold online as TB-500, which the FDA flags for safety risks. Hair studies are in rats and mice only, with no human trials, and animal studies link Tβ4 to tumour spread.

learn Stem Cell Factor

learn SCUBE3

How does SCUBE3 work on hair follicles compared to treatments like minoxidil or finasteride? Laboratory research in mice reports that SCUBE3, a protein released by dermal papilla cells, signals dormant follicles to grow through the TGF-β pathway downstream of Hedgehog; minoxidil and finasteride instead work on blood flow to the follicle and on DHT, and unlike SCUBE3 they have decades of human trial data behind them. SCUBE3 has not been tested in human clinical trials and is not available as a medicine.

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