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signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss
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autoimmune disorder causing patchy hair loss
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natural substance from Neem tree with medicinal and pesticidal properties
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Research
5 / 1000+ resultsresearch Case Series: Gene Expression Analysis in Canine Vogt-Koyanagi-Harada/Uveodermatologic Syndrome and Vitiligo Reveals Conserved Immunopathogenesis Pathways Between Dog and Human Autoimmune Pigmentary Disorders
This study analyzed gene expression in 2 canines with Vogt-Koyanagi-Harada syndrome (VKH) and 1 with vitiligo to explore the immunopathogenesis of these autoimmune pigmentary disorders. The research found that T cell gene signatures, including IFNG, TNF, PRF1, IL15, CTSW, CXCL10, and CCL5, were upregulated in affected dogs compared to healthy controls, mirroring findings in humans. Additionally, genes such as FOXP3 and TBX21 were enriched, while IGFBP5, FOXO1, and PECAM1 were decreased. The study also identified TGFB3, SFRP2, and CXCL7 as potential contributors to these disorders. These findings suggested that the immunopathogenesis of VKH and vitiligo is conserved between dogs and humans, providing insights that could aid in developing targeted therapies and predicting treatment responses.
research ScINSIGHT for Interpreting Single-Cell Gene Expression from Biologically Heterogeneous Data
scINSIGHT accurately identifies cell clusters and gene patterns in complex data.
research Fibroblast Heterogeneity and Functions: Insights from Single-Cell Sequencing in Wound Healing, Breast Cancer, Ovarian Cancer, and Melanoma
Different types of fibroblasts play specific roles in wound healing and cancer, which could help improve treatments.
research Human αβ and γδ T Cells in Skin Immunity and Disease
Certain types of T cells are essential for healthy skin and play a role in skin diseases, but more research is needed to improve treatments.
research Molecular Regulation and Cellular Heterogeneity in Skin Repair and Hair Follicle Regeneration
Ovol2 is crucial for hair growth and skin healing by controlling cell movement and growth.
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5 / 1000+ resultscommunity PP405 Won't Work Long Term: Hair Follicle Damage Due to Abuse of the ISR System
PP405 may damage hair follicles if used long-term, suggesting cycling might be necessary. Combining it with finasteride could help maintain hair growth.
community It works. About a 1 year transformation.
A user's experience with hair loss treatments, specifically Minoxidil and finasteride, which they have used without side effects for a year. Other users shared their experiences and advice about potential side effects and supplements to help.
community JXL082 is not PP405 and Everychem followed the wrong lead
JXL082 is not the same as PP405, leading to a halt in sales and a plan to synthesize the real PP405. There is skepticism about the safety and effectiveness of JXL082 and PP405, with concerns about patent issues and the long-term impact on hair growth.
community PP405 Drug in Action: Picture From Official Company Website
PP405 shows promise for hair follicle reactivation with minimal side effects. Users recommend continuing Minoxidil and Finasteride until more results are confirmed.
community Why balding gets worse in every generation?
Balding seems to worsen with each generation, possibly due to stress, diet, and environmental factors. The user started treatments like Minoxidil and finasteride.