20 citations
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December 2020 in “Frontiers in Immunology” This study analyzed gene expression in 2 canines with Vogt-Koyanagi-Harada syndrome (VKH) and 1 with vitiligo to explore the immunopathogenesis of these autoimmune pigmentary disorders. The research found that T cell gene signatures, including IFNG, TNF, PRF1, IL15, CTSW, CXCL10, and CCL5, were upregulated in affected dogs compared to healthy controls, mirroring findings in humans. Additionally, genes such as FOXP3 and TBX21 were enriched, while IGFBP5, FOXO1, and PECAM1 were decreased. The study also identified TGFB3, SFRP2, and CXCL7 as potential contributors to these disorders. These findings suggested that the immunopathogenesis of VKH and vitiligo is conserved between dogs and humans, providing insights that could aid in developing targeted therapies and predicting treatment responses.
January 2019 in “Springer eBooks” Acne can appear or persist in adulthood due to hormonal changes, external factors, or substance use, and requires appropriate treatment.
15 citations
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November 2020 in “Physiological reports” Sox6 is important in heart and kidney health, affecting diseases like diabetes, heart disease, and high blood pressure.
10 citations
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August 2022 in “International Journal of Molecular Sciences” Leptin-deficient mice, used as a model for Type 2 Diabetes, have delayed wound healing due to impaired contraction and other dysfunctional cellular responses.
8 citations
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November 2019 in “Clinical Science” High DHA levels delay wound healing and worsen skin repair quality.