Emerging Roles of Sox6 in the Renal and Cardiovascular Systems
November 2020
in “
Physiological reports
”
TLDR Sox6 is important in heart and kidney health, affecting diseases like diabetes, heart disease, and high blood pressure.
The document reviewed the emerging roles of the transcription factor Sox6 in the renal and cardiovascular systems, highlighting its involvement in various diseases such as diabetic nephropathy, cardiomyopathy, and hypertension. Sox6 regulated renin expression and juxtaglomerular cell recruitment in the kidney, influenced muscle performance and gene expression in cardiac and skeletal muscles, and was linked to apoptosis and reduced heart efficiency in cardiomyocytes. Overexpression of Sox6 was associated with reduced insulin synthesis and increased apoptosis in pancreatic β-cells, implicating it in diabetes. The review emphasized the multifaceted functions of Sox6 in gene regulation and its potential as a therapeutic target, while noting the need for further research to fully understand its diverse roles in adult tissues.
