TLDR Sox21 is crucial for tooth development and enamel formation by preventing cells from changing into a different type.
The study investigated the role of Sox21 in regulating Anapc10 expression and its impact on the fate of ectodermal organs, particularly focusing on dental epithelium and hair follicles. Sox21 was found to be crucial for proper ameloblast differentiation and enamel formation, as its disruption led to severe enamel hypoplasia and ectopic hair formation in the gingiva of Sox21 knockout mice. Sox21 regulated Anapc10, which influenced the stability of EMT-related proteins, and its deficiency caused ameloblasts to trans-differentiate into hair cells. The findings highlighted Sox21's essential role in maintaining dental epithelial identity and preventing aberrant EMT, suggesting potential therapeutic targets for hair loss conditions.
2 citations
,
October 2012 in “Experimental Dermatology” Deleting the Sox21 gene changes hair lipid composition and increases cholesterol sulfate levels.
87 citations
,
July 2009 in “The journal of investigative dermatology/Journal of investigative dermatology” Human beard hair medulla contains a unique and complex mix of keratins not found in other human tissues.
73 citations
,
May 2009 in “Proceedings of the National Academy of Sciences” Disrupting the Sox21 gene in mice causes hair loss and regrowth cycles.
70 citations
,
December 2004 in “Differentiation” The study identified and characterized new keratin genes linked to hair follicles and epithelial tissues.
50 citations
,
July 2008 in “British Journal of Dermatology” 138 citations
,
March 2007 in “Experimental cell research” Only a few hair-specific keratins are linked to inherited hair disorders.
276 citations
,
January 2005 in “International review of cytology” More research is needed to understand how hair keratins work and their role in hair disorders.
199 citations
,
January 2004 in “The International Journal of Developmental Biology” Hair follicle growth and development are controlled by specific genes and molecular signals.
29 citations
,
April 2003 in “Experimental dermatology” Human hair follicles grown in vitro maintain normal keratin patterns and structure.
