Sox21 Regulates Anapc10 Expression and Determines the Fate of Ectodermal Organs

    June 2020 in “ iScience ”
    Kan Saito, Fréderic Michon, Aya Yamada … Satoshi Fukumoto
    Studysummary This study found that disrupting Sox21 in developing teeth leads to severe enamel hypoplasia, regional osteoporosis, and abnormal hair formation, with impaired dental epithelial differentiation and regulation of hair follicle cell fate.
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    Research cited in this study 5

    1. Deletion of the Sox21 Gene Drastically Affects Hair Lipids Experimental Dermatology · 2012
    2. Sox2-Positive Dermal Papilla Cells Specify Hair Follicle Type in Mammalian Epidermis Development · 2009
    3. The Keratins of the Human Beard Hair Medulla: The Riddle in the Middle ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2009
    4. The Disruption of Sox21-Mediated Hair Shaft Cuticle Differentiation Causes Cyclic Alopecia in Mice Proceedings of the National Academy of Sciences · 2009
    5. The Human Type I Keratin Gene Family: Characterization of New Hair Follicle Specific Members and Evaluation of the Chromosome 17q21.2 Gene Domain Differentiation · 2004

    Related research 5

    1. Characterization and Expression Analysis of the Hair Keratin Associated Protein KAP26.1 British Journal of Dermatology · 2008
    2. Hair Follicle-Specific Keratins And Their Diseases Experimental cell research · 2007
    3. Keratins of the Human Hair Follicle International review of cytology · 2005
    4. Hair Follicle Differentiation And Regulation The International Journal of Developmental Biology · 2004
    5. Hair Keratin Pattern in Human Hair Follicles Grown In Vitro Experimental dermatology · 2003