TLDR SOX9 is essential for the development of various organs and hair follicles.
The document discusses the role of the protein SOX9 in organogenesis, or the formation of organs during embryonic development. SOX9 is crucial in the development of various organs including cartilage, testis, and hair follicle. It is involved in chondrocyte differentiation and proliferation in cartilage, Sertoli cell differentiation and testis determination, and the survival of mesenchymal cells and chondrocytes. SOX9 also plays a role in the development of the nervous system, retina, lung, heart valve, pancreas, bile duct, intestine, and prostate. In hair follicles, SOX9 is expressed in hair follicle stem cells and is involved in hair follicle morphogenesis and cycling. It is crucial for matrix cell proliferation and the maintenance of hair follicle stem cells. When SOX9 is removed, it leads to impaired proliferative capacity in the matrix cells, loss of the hair follicle stem cell marker CD34, and loss of external hair.
321 citations,
March 2015 in “Nature” Super-enhancers controlled by pioneer factors like SOX9 are crucial for stem cell adaptability and identity.
788 citations,
February 2007 in “Nature” The document concludes that skin stem cells are important for hair growth and wound healing, and could be used in regenerative medicine.
949 citations,
January 2001 in “Cell” Adult mouse skin contains stem cells that can create new hair, skin, and oil glands.
759 citations,
February 2009 in “Current Biology” Hair follicles are complex, dynamic mini-organs that help us understand cell growth, death, migration, and differentiation, as well as tissue regeneration and tumor biology.
396 citations,
May 2011 in “Cell stem cell” Nerve signals are crucial for hair follicle stem cells to become skin stem cells and help in wound healing.
1 citations,
December 2023 in “The journal of investigative dermatology/Journal of investigative dermatology” Keeping β-catenin levels high in mammary cells disrupts their development and branching.
36 citations,
October 2015 in “Cell reports” Gab1 protein is crucial for hair growth and stem cell renewal, and Mapk signaling helps maintain these processes.
August 2023 in “bioRxiv (Cold Spring Harbor Laboratory)” Too much β-catenin activity can mess up the development of mammary glands and make them more like hair follicles.
1 citations,
February 2023 in “ACS Biomaterials Science & Engineering” The new microwell device helps grow more hair stem cells that can regenerate hair.