SOX9 in Organogenesis: Shared and Unique Transcriptional Functions

September 2022 in “ Cellular and Molecular Life Sciences ”

Zhenhua Ming, Brittany Vining, Stefan Bagheri‐Fam, Vincent R. Harley

SOX9 hair follicle hair follicle stem cells hair follicle morphogenesis hair follicle cycling matrix cell proliferation CD34 mesenchymal cells chondrocytes

Studysummary This review discusses the roles of the transcription factor SOX9 in organ development and maintenance, providing insights into its regulation and diverse functions, but reports no new experimental results.

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Research cited in this study

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research Pioneer Factors Govern Super-Enhancer Dynamics in Stem Cell Plasticity and Lineage Choice

321 citations , March 2015 in “Nature”

This study found that super-enhancers are essential for hair follicle stem cell identity, lineage commitment, and plasticity in mice, with SOX9 being a key regulator of these chromatin dynamics.

research Scratching the Surface of Skin Development

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This review explores how adult skin epithelia preserve stem cell populations for hair follicle regeneration and wound healing, but reports no new experimental results.

research Morphogenesis and Renewal of Hair Follicles from Adult Multipotent Stem Cells

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This study demonstrated that multipotent stem cells in adult mice whisker follicles migrate to produce whisker growth, and that this process requires precise control of stem cell trafficking.