TLDR High DHA levels delay wound healing and worsen skin repair quality.
The study found that increased levels of docosahexaenoic acid (DHA) in mice, both endogenously produced in FAT-1 transgenic mice and supplemented with DHA-rich fish oil, slowed the resolution of inflammation and impaired the quality of healed skin tissue. This was evidenced by prolonged inflammation, increased inflammatory markers like TNF-α, and altered collagen fiber organization. Despite DHA's known anti-inflammatory properties, its elevated levels led to delayed wound healing and poor tissue quality, suggesting a need for caution in DHA supplementation, especially when tissue repair is critical. The study included 8-16 mice per group, providing a robust sample size for these findings.
145 citations,
November 2018 in “Nature Communications” The Sonic hedgehog pathway is crucial for new hair growth during mouse skin healing.
68 citations,
November 2012 in “Journal of Investigative Dermatology” Prostaglandin D2 blocks new hair growth after skin injury through the Gpr44 receptor.
23 citations,
August 2018 in “Biochimica and biophysica acta. Molecular and cell biology of lipids” Different sPLA2 enzymes affect immunity, skin and hair health, reproduction, and may be potential targets for therapy.
53 citations,
January 2017 in “BioMed research international” Genetically modified plants could be an important source of omega-3 fats to meet global needs.
16 citations,
January 2022 in “International journal of molecular sciences” Certain daily habits like stress, diet, and sleep can affect the severity of hair loss in alopecia areata.
24 citations,
December 2018 in “Inflammation and Regeneration” Phospholipase A2 enzymes play key roles in skin health and disease.
April 2011 in “한국생물공학회 학술대회” Lotion with fucoidan from brown seaweed improved skin and reduced allergy symptoms in mice with dermatitis.
