Docosahexaenoic Acid Slows Inflammation Resolution and Impairs the Quality of Healed Skin Tissue

    November 2019 in “ Clinical Science ”
    Thamiris Candreva, Carolina Meneguetti Cintra Kühl, Beatriz Bürger, MARIAH B. P. DOS ANJOS, Márcio Alberto Torsoni, Sílvio Roberto Consonni, Amanda Rabello Crisma, Helena L. Fisk, Philip C. Calder, Felipe Cézar Pinheiro de Mato, Erica Moraes Sernaglia, Marco Aurélio Ramirez Vinolo, Hosana Gomes Rodrigues
    TLDR High DHA levels delay wound healing and worsen skin repair quality.
    The study investigated the effects of omega-3 fatty acids, particularly docosahexaenoic acid (DHA), on skin wound healing using FAT-1 transgenic mice and wild-type mice supplemented with DHA-enriched fish oil. Both groups with elevated DHA levels showed delayed wound closure, increased inflammation markers (TNF-α), and reduced anti-inflammatory IL-10. This prolonged inflammation resulted in poorer quality of healed skin tissue, characterized by disorganized collagen fibers and structural defects. The findings suggested that high DHA content slowed inflammation resolution and impaired the quality of skin repair.
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