Docosahexaenoic Acid Slows Inflammation Resolution and Impairs the Quality of Healed Skin Tissue

    November 2019 in “ Clinical Science ”
    Thamiris Candreva, Carolina Meneguetti Cintra Kühl, Beatriz Bürger, MARIAH B. P. DOS ANJOS, Márcio Alberto Torsoni, Sílvio Roberto Consonni, Amanda Rabello Crisma, Helena L. Fisk, Philip C. Calder, Felipe Cézar Pinheiro de Mato, Erica Moraes Sernaglia, Marco Aurélio Ramirez Vinolo, Hosana Gomes Rodrigues
    TLDR High DHA levels delay wound healing and worsen skin repair quality.
    The study found that increased levels of docosahexaenoic acid (DHA) in mice, both endogenously produced in FAT-1 transgenic mice and supplemented with DHA-rich fish oil, slowed the resolution of inflammation and impaired the quality of healed skin tissue. This was evidenced by prolonged inflammation, increased inflammatory markers like TNF-α, and altered collagen fiber organization. Despite DHA's known anti-inflammatory properties, its elevated levels led to delayed wound healing and poor tissue quality, suggesting a need for caution in DHA supplementation, especially when tissue repair is critical. The study included 8-16 mice per group, providing a robust sample size for these findings.
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