Group IID, IIE, IIF, and III Secreted Phospholipase A2s

The document from 2019 discusses the roles of groups IID, IIE, IIF, and III secreted phospholipase A2s (sPLA2s) in various biological processes. sPLA2-IID is involved in immune suppression by regulating omega-3 polyunsaturated fatty acid metabolites, which can dampen adaptive immunity but may exacerbate conditions like viral infections and cancer. sPLA2-IIE is implicated in metabolic regulation and hair follicle homeostasis, with its deficiency causing skin and hair abnormalities. sPLA2-IIF is associated with epidermal homeostasis and diseases, where its overexpression leads to psoriasis-like epidermal hyperplasia and alopecia, and its deficiency protects against skin tumors and hyperplasia in psoriasis models. sPLA2-III plays a role in male reproduction, anaphylaxis, colonic diseases, and possibly atherosclerosis, with its deficiency leading to reduced sperm motility and fertility, and its overexpression increasing susceptibility to colon cancer and colitis. The document emphasizes the potential of these enzymes as therapeutic targets and the importance of lipidomics in understanding their functions. The specific number of mice used in the study is not provided.