Hair Follicular Expression and Function of Group X Secreted Phospholipase A2 in Mouse Skin
January 2011
in “
Journal of Biological Chemistry
”
group X secreted phospholipase A2 sPLA2-X anagen phase alopecia hair follicle distortion hyperplasia epidermis sebaceous glands proteolytic activation phosphatidylethanolamine eicosanoid production Pla2g10-deficient hair gene expression outer root sheath melanin granules prostanoid synthesis hair follicle homeostasis prostanoid pathway hair loss hair growth phase skin thickening oil glands enzyme activation fatty acids inflammatory molecules gene expression hair root sheath skin pigment prostaglandins hair health inflammatory pathway
TLDR sPLA2-X is crucial for normal hair growth and follicle health.
The study investigated the role of Group X secreted phospholipase A2 (sPLA2-X) in mouse hair follicles, revealing that sPLA2-X was highly expressed in hair follicles and played a crucial role in hair growth and skin barrier function. Overexpression of sPLA2-X in transgenic mice led to hair follicle distortion, alopecia, and epidermal hyperplasia, while deficiency in sPLA2-X resulted in abnormal hair follicles and reduced hair growth. The enzyme's activity was linked to the hydrolysis of phospholipids, producing bioactive lipids like arachidonic acid and prostaglandin E2, which are involved in hair and skin homeostasis. The findings suggested that sPLA2-X could be a potential target for treating hair loss and improving skin health.
