Hair Follicular Expression and Function of Group X Secreted Phospholipase A2 in Mouse Skin

    January 2011 in “ Journal of Biological Chemistry ”
    Christoph J. Binder, Yoshitaka Taketomi, Yuki Isogai, Yoshimi Miki, Hiroyasu Sato, Seiko Masuda, Yasumasa Nishito, Kiyokazu Morioka, Yoshikazu Ishimoto, Noriko Suzuki, Yasunori Yokota, Kohji Hanasaki, Yukio Ishikawa, Toshiharu Ishii, Tetsuyuki Kobayashi, Kiyoko Fukami, Kazutaka Ikeda, Hiroki Nakanishi, Ryo Taguchi, Makoto Murakami
    TLDR sPLA2-X is crucial for normal hair growth and follicle health.
    The study investigated the role of Group X secreted phospholipase A2 (sPLA2-X) in mouse hair follicles, revealing that sPLA2-X was highly expressed in hair follicles and played a crucial role in hair growth and skin barrier function. Overexpression of sPLA2-X in transgenic mice led to hair follicle distortion, alopecia, and epidermal hyperplasia, while deficiency in sPLA2-X resulted in abnormal hair follicles and reduced hair growth. The enzyme's activity was linked to the hydrolysis of phospholipids, producing bioactive lipids like arachidonic acid and prostaglandin E2, which are involved in hair and skin homeostasis. The findings suggested that sPLA2-X could be a potential target for treating hair loss and improving skin health.
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