9 citations
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April 1970 in “Biochemical pharmacology” Stilbamidine and hydroxystilbamidine inhibit enzyme release from lysosomes and have effects similar to cortisol and chloroquine.
20 citations
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December 2020 in “Frontiers in Immunology” This study analyzed gene expression in 2 canines with Vogt-Koyanagi-Harada syndrome (VKH) and 1 with vitiligo to explore the immunopathogenesis of these autoimmune pigmentary disorders. The research found that T cell gene signatures, including IFNG, TNF, PRF1, IL15, CTSW, CXCL10, and CCL5, were upregulated in affected dogs compared to healthy controls, mirroring findings in humans. Additionally, genes such as FOXP3 and TBX21 were enriched, while IGFBP5, FOXO1, and PECAM1 were decreased. The study also identified TGFB3, SFRP2, and CXCL7 as potential contributors to these disorders. These findings suggested that the immunopathogenesis of VKH and vitiligo is conserved between dogs and humans, providing insights that could aid in developing targeted therapies and predicting treatment responses.
19 citations
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January 2017 in “Stem Cells International” Adipose-derived stem cells show promise in treating skin conditions like vitiligo, alopecia, and nonhealing wounds.
3 citations
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September 2023 in “Skin research and technology” New treatments for skin damage from UV light using stem cells and their secretions show promise for skin repair without major risks.
1 citations
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January 2021 CD4+ skin cells may be precursors to basal cell carcinoma.
