Studies on Lysosomes—XIII: Effects of Stilbamidine and Hydroxystilbamidine on Lysosomal Enzyme Release in Rabbit Liver
April 1970
in “
Biochemical pharmacology
”
Studysummary This study found that stilbamidine and hydroxystilbamidine can inhibit the release of specific enzymes from lysosomes and mitochondria in rabbit liver at certain concentrations, with effects similar to cortisol and chloroquine. Our plain-language summary of this paper — not a Tressless recommendation.
The study investigated the effects of stilbamidine and hydroxystilbamidine on lysosomal enzyme release in rabbit liver. At concentrations between 5 × 10⁻⁵ M and 5 × 10⁻⁴ M, these compounds inhibited the release of aryl sulfatase and cathepsin without affecting the free activity of lysosomal hydrolases. At higher concentrations (10⁻³ M), they inhibited lysosomal β-glycerol phosphatase, β-glucuronidase, and aryl sulfatase. Stilbamidines also inhibited enzyme release induced by various agents and retarded the release of malate dehydrogenase from mitochondria. Additionally, stilbamidine antagonized vitamin A palmitate-induced ear collapse in rabbits and inhibited lymphocyte transformation. The effects were similar to those of cortisol and chloroquine.
