Studies on Lysosomes—XIII: Effects of Stilbamidine and Hydroxystilbamidine on Lysosomal Enzyme Release in Rabbit Liver
April 1970
in “
Biochemical pharmacology
”
TLDR Stilbamidine and hydroxystilbamidine inhibit enzyme release from lysosomes and have effects similar to cortisol and chloroquine.
The study investigated the effects of stilbamidine and hydroxystilbamidine on lysosomal enzyme release in rabbit liver. At concentrations between 5 × 10⁻⁵ M and 5 × 10⁻⁴ M, these compounds inhibited the release of aryl sulfatase and cathepsin without affecting the free activity of lysosomal hydrolases. At higher concentrations (10⁻³ M), they inhibited lysosomal β-glycerol phosphatase, β-glucuronidase, and aryl sulfatase. Stilbamidines also inhibited enzyme release induced by various agents and retarded the release of malate dehydrogenase from mitochondria. Additionally, stilbamidine antagonized vitamin A palmitate-induced ear collapse in rabbits and inhibited lymphocyte transformation. The effects were similar to those of cortisol and chloroquine.
