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    Did you mean Hypoxia-Inducible Factor 1-alpha?
    Glossary Hypoxia-Inducible Factor 1-alpha

    protein that helps cells adapt to low oxygen levels

    Hypoxia-Inducible Factor 1-alpha (HIF-1α) is a protein that helps cells respond to low oxygen levels (hypoxia). It activates various genes that enable cells to adapt to hypoxic conditions, such as those involved in increasing blood supply and altering metabolism. This protein is crucial in processes like wound healing and can also play a role in diseases like cancer, where it can help tumors grow by improving their oxygen supply.

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    1. A combination of pyridine‐2, 4‐dicarboxylic acid diethyl ester and resveratrol stabilizes hypoxia‐inducible factor 1‐alpha and improves hair density in female volunteers International Journal of Cosmetic Science · 2020 · 8 citations
    2. Overexpression of hypoxia-inducible factor-1α in hidradenitis suppurativa: the link between deviated immunity and metabolism Archives of dermatological research · 2023 · 5 citations
    3. Hypoxia inducible factor-1α promotes trichogenic gene expression in human dermal papilla cells Scientific Reports · 2023 · 2 citations
    4. Insights into male androgenetic alopecia using comparative transcriptome profiling: hypoxia-inducible factor-1 and Wnt/β-catenin signalling pathways British Journal of Dermatology · 2022 · 1 citations
    5. Hypoxia inducible factor-1a promotes trichogenic gene expression in human dermal papilla cells Research Square (Research Square) · 2022 · 1 citations
    6. Iron Chelators in the Management of Autoimmune-Induced Alopecia: A Focus on Hypoxia-Inducible Factor 1 Modulation and Hair Restoration Journal of Clinical Medicine · 2025
    7. The potential role of hypoxia inducible factor 1 alpha in multipotent germ cells and neural stem/progenitor cells ScholarSpace (University of Hawaii at Manoa) · 2014
    8. Cepharanthine induces the proliferation of human dermal papilla cells and stimulates vascular endothelial growth factor expression through increased intracellular calcium mobilization and hypoxia‐inducible factor activation Clinical and Experimental Dermatology · 2020 · 7 citations
    9. Immunohistochemical Analysis of the Mechanistic Target of Rapamycin and Hypoxia Signalling Pathways in Basal Cell Carcinoma and Trichoepithelioma PloS one · 2014 · 15 citations
    10. Naturally Occurring Hair Growth Peptide: Water-Soluble Chicken Egg Yolk Peptides Stimulate Hair Growth Through Induction of Vascular Endothelial Growth Factor Production Journal of Medicinal Food · 2018 · 6 citations
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