Secreted Frizzled-Related Protein 4 Inhibits the Regeneration of Hair Follicles

    January 2019 in “ PeerJ ”
    Haiying Guo, Yizhan Xing, Fang Deng, Kang Yang, Yuhong Li
    Image of study
    TLDR A protein called sFRP4 can slow down hair regrowth.
    The 2019 study investigated the role of Secreted Frizzled-related Protein 4 (sFRP4) in hair follicle regeneration. Researchers found that sFRP4, a protein expressed in both human and mouse hair follicles, inhibits hair follicle regeneration when overexpressed. However, the structure of hair follicles remained intact and the growth was not completely blocked. The protein works by preventing the nuclear translocation of β-catenin, a key protein in the Wnt signaling pathway crucial for hair growth. These findings suggest that sFRP4 could be a potential target for therapies aimed at promoting hair growth and treating conditions like alopecia.
    Discuss this study in the Community →

    Research cited in this study

    6 / 6 results

    Related Community Posts Join

    6 / 16 results
      Diffuse hair loss and scalp biopsies

      community Diffuse hair loss and scalp biopsies

      in Research  692 upvotes 3 months ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community Fats on your Head to Stop Hair Loss?

      in Research/Science  138 upvotes 9 months ago
      The conversation discusses the potential of long-chain unsaturated fatty acids, like oleic and linoleic acid, as an additional treatment for hair loss, which may inhibit the enzyme responsible for converting testosterone to DHT and promote hair growth. Users humorously suggest using oils topically and discuss other hair loss treatments, but the main focus is on the science behind fatty acids and their role in hair health.

      community [25, F] [RANT] Shedding since March 2020. This just isn’t fair.

      in Female  42 upvotes 3 years ago
      User "missbloombastic" has been experiencing hair loss since 2016 and tried min, fin, multivitamins, and spiro with mixed results. Another user shares their struggle with hair loss and its impact on self-esteem, while a third user suggests checking blood tests and confirming the cause of hair loss.

      community No, Finasteride as a treatment for MPB was not an "accident"

      in Research/Science  105 upvotes 3 years ago
      Finasteride was intentionally developed to treat BPH and later approved for male pattern baldness (MPB) due to its 5AR inhibition effects. The delay in MPB approval was due to concerns about off-label use for female hirsutism and the prioritization of treating a more debilitating condition.

    Related Research

    5 / 5 results