Secreted Frizzled-Related Protein 4 Inhibits the Regeneration of Hair Follicles

January 2019 in “ PeerJ ”

Haiying Guo, Yizhan Xing, Fang Deng, Kang Yang, Yuhong Li

Secreted Frizzled-related Protein 4 sFRP4 hair follicle regeneration β-catenin Wnt signaling pathway alopecia hair growth hair loss

TLDR A protein called sFRP4 can slow down hair regrowth.

The 2019 study investigated the role of Secreted Frizzled-related Protein 4 (sFRP4) in hair follicle regeneration. Researchers found that sFRP4, a protein expressed in both human and mouse hair follicles, inhibits hair follicle regeneration when overexpressed. However, the structure of hair follicles remained intact and the growth was not completely blocked. The protein works by preventing the nuclear translocation of β-catenin, a key protein in the Wnt signaling pathway crucial for hair growth. These findings suggest that sFRP4 could be a potential target for therapies aimed at promoting hair growth and treating conditions like alopecia.

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research Paracrine Secreted Frizzled-Related Protein 4 Inhibits Melanocyte Differentiation in Hair Follicle

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research Self-Organizing and Stochastic Behaviors During the Regeneration of Hair Stem Cells

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5 / 5 results

research Secreted Frizzled-Related Protein 4 Inhibits the Regeneration of Hair Follicles

7 citations , January 2019 in “PeerJ”

A protein called sFRP4 can slow down hair regrowth.

research Paracrine Secreted Frizzled-Related Protein 4 Inhibits Melanocyte Differentiation in Hair Follicle

8 citations , January 2017 in “Stem Cells International”

A protein called sFRP4 from skin cells stops the development of pigment-producing cells in hair.

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research Beta-Catenin Activity in the Dermal Papilla Regulates Morphogenesis and Regeneration of Hair

314 citations , April 2010 in “Developmental Cell”

β-catenin in the dermal papilla is crucial for normal hair growth and repair.

research Hair Cycle and Hair Pigmentation: Dynamic Interactions and Changes Associated with Aging

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