Adipose-Derived Stem Cell Exosomes Antagonize the Inhibitory Effect of Dihydrotestosterone on Hair Follicle Growth by Activating Wnt/Beta-Catenin Pathway

The research paper conducted experiments on human hair follicle organs, in vitro dermal papilla cells, and in vivo animal models to study the effects of adipose-derived stem cell exosomes (ADSC-Exos) on hair growth. The study found that ADSC-Exos promoted hair growth and counteracted the inhibitory effects of dihydrotestosterone (DHT), a hormone linked to hair loss. ADSC-Exos were found to activate the Wnt/β-catenin pathway, which is crucial for hair follicle formation, development, and regeneration. In the mouse model, ADSC-Exos were more effective than minoxidil, a common hair growth treatment. The study suggests that ADSC-Exos could be a potential therapeutic approach for hair loss conditions like androgenetic alopecia (AGA). However, the specific component in ADSC-Exos that activates the Wnt/β-catenin signaling pathway remains unspecified.