Proliferation and Differentiation of Cultured Human Keratinocytes Is Modulated by 1,25-Dihydroxyvitamin D3 and Synthetic Vitamin D3 Analogues in a Cell Density-, Calcium-, and Serum-Dependent Manner

    January 1997 in “ Pharmacology & toxicology ”
    Mathias Tiedemann Svendsen, Guy Daneels, Johan Geysen … Knud Kragballe
    Studysummary This study found that human keratinocytes' sensitivity and response to vitamin D3 analogues vary based on cell density, serum availability, and calcium concentration.
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    Research cited in this study 2

    1. Biphasic Effect of 1,25-Dihydroxyvitamin D3 on Human Hair Follicle Growth and Hair Fiber Production in Whole-Organ Cultures ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 1994
    2. Topically Active Vitamin D3 Analogue, 1α,24-Dihydroxy-Cholecalciferol, Has an Anti-Proliferative Effect on the Epidermis of Guinea Pig Skin British journal of dermatology/British journal of dermatology, Supplement · 1987