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Glossary Cell Density

number of cells in a specific volume or area

Cell density refers to the number of cells present in a given volume or area of a tissue or culture. In the context of hair and alopecia, understanding cell density can help researchers determine the health and growth potential of hair follicles, as higher cell density in hair follicles might indicate robust hair growth, while lower cell density could be associated with thinning hair or hair loss.

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Research

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research Proliferation and Differentiation of Cultured Human Keratinocytes is Modulated by 1,25(OH)₂D₃ and Synthetic Vitamin D₃ Analogues in a Cell Density‐, Calcium‐ and Serum‐Dependent Manner*

39 citations , January 1997 in “Pharmacology & toxicology”

This study found that human keratinocytes' sensitivity and response to vitamin D3 analogues vary based on cell density, serum availability, and calcium concentration.

research Cell Density-Dependent Upregulation of PDCD4 in Keratinocytes and Its Implications for Epidermal Homeostasis and Repair

10 citations , December 2015 in “International Journal of Molecular Sciences”

This study suggests that PDCD4 regulates keratinocyte proliferation and contact inhibition, playing a role in epidermal homeostasis and wound healing.

research The Effects of Lower vs Higher Cell Number of Platelet-Rich Plasma (PRP) on Hair Density and Diameter in Androgenetic Alopecia (AGA): A Randomized, Double-Blinded, Placebo, Parallel-Group Half-Scalp IRB-Approved Study.

6 citations , May 2021 in “Aesthetic Surgery Journal”

This study found that intradermal injections of platelet-rich plasma were equally safe and effective for treating androgenetic alopecia, with higher platelet numbers possibly enhancing hair density and follicle diameter.

research 653 Substance P ameliorates epidermal thickness, basal cell density, and asymmetric stem cell self-renewal in skin with decreased sensory innervation

July 2024 in “Journal of Investigative Dermatology”

Substance P helps restore skin thickness and cell renewal when sensory nerves are reduced.

research Control of myeloid cell density in barrier tissues

11 citations , June 2020 in “FEBS Journal”

This review discusses the regulation of myeloid cell networks in barrier tissues and how various factors influence immune homeostasis, but it reports no new experimental results.

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Community Join

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community New Hair Loss Treatment: Adipose Derived Secretomes

18 upvotes 1 year ago

Adipose-derived stem cell secretome showed significant improvement in hair density and growth, especially when combined with minoxidil, suggesting a synergistic effect. The study had limitations, including a small sample size and potential bias.

community Has anyone here actually undergone experimental (grey market) hair cell therapy/follicle cloning?

7 upvotes 5 months ago

Hair cell therapy and follicle cloning are still in experimental stages, with treatments like hair multiplication and regenerative hair therapy being marketed but not yet proven to create unlimited new follicles. There is skepticism about the effectiveness and legitimacy of these treatments, with some considering them scams.

community What do you guys think of stem cell hai restoration?

10 upvotes 9 months ago

Stem cell hair restoration lacks scientific evidence and is often considered a scam. Effective hair loss treatments include hair transplants, Minoxidil, and Finasteride, but stem cell treatments are not proven.

community Stem-cell hair transplants! 20k lab grown grafts from one single graft

50 upvotes 2 years ago

Stem-cell hair transplants could potentially create thousands of grafts from a single donor graft, offering a solution for hair loss with DHT-resistant hair. Companies like Stemson Therapeutics and OrganTech are working on this technology, which may become available in the future, possibly reducing the cost and making it widely accessible.

community Anyone heard of HairStemCell Transplant? They claim not needing to pull the entire hair cell, allowing reuse of same donor area.

4 upvotes 8 years ago

HairStemCell Transplant claims to reuse the donor area without removing the entire hair cell, but results in finer hair that may not regrow after cycles. The technique is costly and less effective than traditional transplants for full coverage.

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Learn

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learn Exosomes

Tiny cell-derived particles offered by clinics as an injectable treatment

learn Ketoconazole

Antifungal, best known as a dandruff shampoo

learn Platelet-Rich Plasma

Concentrate of your own blood platelets, injected into the scalp

learn Microneedling

Technique that makes tiny punctures in the scalp with fine needles

learn Stemoxydine

Cosmetic ingredient made by L'Oréal

learn Stem Cell Factor

What is stem cell factor and why is it used in hair growth treatments? Stem cell factor is a signalling protein linked to hair colour in lab and mouse studies; it is not a proven hair-loss treatment in people.
Does stem cell factor help activate dormant hair follicles? Lab and mouse studies link stem cell factor to hair colour; it has not been shown to reactivate dormant hair follicles in people.
Are stem cell factor products safe for long-term scalp use? Long-term safety of stem cell factor scalp products has not been studied in people; the one human trial of injected stem cell factor reported skin reactions and lasting dark patches.
All 5 questions on Stem Cell Factor →

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Clinics

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