Human Hair Follicle Mesenchymal Stem Cell-Derived Exosome Attenuates UVB-Induced Photoaging Via The miR-125b-5p/TGF-β1/Smad Axis

    December 2024 in “ Biomaterials Research ”
    Cui Hong, Luo‐Qin Fu, Yan Teng, Jincai He, Ye-Yu Shen, Qiong Bian, Tingzhang Wang, Meixia Wang, Xuexia Pang, Zhiwei Lin, Mingang Zhu, Yu Cai, Yangyang Li, Jinyang Chen, Xiaozhou Mou, Yibin Fan
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    TLDR Exosomes from hair stem cells can reduce skin aging from UVB exposure.
    The study investigates the effects of exosomes derived from human hair follicle mesenchymal stem cells on UVB-induced photoaging. The research highlights that these exosomes can mitigate photoaging through the miR-125b-5p/TGF-β1/Smad signaling pathway. This suggests a potential therapeutic approach for skin aging caused by UVB exposure, leveraging the regenerative properties of stem cell-derived exosomes. The findings provide a promising avenue for developing treatments to combat photoaging and improve skin health.
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