Human Hair Follicle Mesenchymal Stem Cell-Derived Exosome Attenuates UVB-Induced Photoaging Via The miR-125b-5p/TGF-β1/Smad Axis

December 2024 in “ Biomaterials Research ”

Cui Hong, Luo‐Qin Fu, Yan Teng, Jincai He, Ye-Yu Shen, Qiong Bian, Tingzhang Wang, Meixia Wang, Xuexia Pang, Zhiwei Lin, Mingang Zhu, Yu Cai, Yangyang Li, Jinyang Chen, Xiaozhou Mou, Yibin Fan

human hair follicle mesenchymal stem cells exosomes UVB-induced photoaging miR-125b-5p TGF-β1 Smad signaling pathway photoaging skin aging stem cell-derived exosomes stem cells UVB photoaging

TLDR Exosomes from hair stem cells can reduce skin aging from UVB exposure.

The study investigates the effects of exosomes derived from human hair follicle mesenchymal stem cells on UVB-induced photoaging. The research highlights that these exosomes can mitigate photoaging through the miR-125b-5p/TGF-β1/Smad signaling pathway. This suggests a potential therapeutic approach for skin aging caused by UVB exposure, leveraging the regenerative properties of stem cell-derived exosomes. The findings provide a promising avenue for developing treatments to combat photoaging and improve skin health.

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