Dermal Papilla Cell-Derived Extracellular Vesicles Increase Hair Inductive Gene Expression in Adipose Stem Cells via β-Catenin Activation

    January 2022 in “ Cells ”
    Taheruzzaman Kazi, Abir Nagata, Takatoshi Nakagawa … Shigeki Inui
    Studysummary This study found that early passage dermal papilla cell-derived extracellular vesicles, combined with specialized medium, helped adipose-derived stem cells develop dermal papilla-like properties.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 15

    1. Neural Progenitor Cell-Derived Nanovesicles Promote Hair Follicle Growth via miR-100 Journal of nanobiotechnology · 2021
    2. Dermal Exosomes Containing miR-218-5p Promote Hair Regeneration by Regulating β-Catenin Signaling Science Advances · 2020
    3. Optimal Stimulation Toward the Dermal Papilla Lineage Can Be Promoted by Combined Use of Osteogenic and Adipogenic Inducers FEBS open bio · 2019
    4. Activation of Wnt/β-Catenin Signaling Is Involved in Hair Growth-Promoting Effect of 655-nm Red Light and LED in In Vitro Culture Model Lasers in Medical Science · 2018
    5. miR-195-5p Regulates Hair Follicle Inductivity of Dermal Papilla Cells by Suppressing Wnt/β-Catenin Activation BioMed Research International · 2018
    6. Extracellular Vesicles Derived from MSCs Activate Dermal Papilla Cells In Vitro and Promote Hair Follicle Conversion from Telogen to Anagen in Mice Scientific Reports · 2017
    7. Fibroblast Growth Factors Stimulate Hair Growth Through Beta-Catenin and Shh Expression in C57BL/6 Mice BioMed Research International · 2015
    8. MicroRNA-214 Controls Skin and Hair Follicle Development by Modulating the Activity of the Wnt Pathway Journal of Cell Biology · 2014
    9. Prospect of Stem Cell Conditioned Medium in Regenerative Medicine BioMed Research International · 2014
    10. Therapeutic Strategy for Hair Regeneration: Hair Cycle Activation, Niche Environment Modulation, Wound-Induced Follicle Neogenesis, and Stem Cell Engineering Expert Opinion on Biological Therapy · 2013
    11. Pattern Hair Loss in Men: Diagnosis, Genetic Link, Clinical Features, and Treatments Dermatologic Clinics · 2012
    12. Adipocyte Lineage Cells Contribute to the Skin Stem Cell Niche to Drive Hair Cycling Cell · 2011
    13. Sox2-Positive Dermal Papilla Cells Specify Hair Follicle Type in Mammalian Epidermis Development · 2009
    14. Human Follicular Papilla Cells Carry Out Non-Adipose Tissue Production of Leptin Journal of Investigative Dermatology · 2001
    15. Osteopontin Gene Is Expressed in the Dermal Papilla of Pelage Follicles in a Hair-Cycle-Dependent Manner Journal of Investigative Dermatology · 2001