Dermal Papilla Cell-Derived Extracellular Vesicles Increase Hair Inductive Gene Expression in Adipose Stem Cells via β-Catenin Activation

January 2022 in “ Cells ”

Taheruzzaman Kazi, Abir Nagata, Takatoshi Nakagawa, Takashi Matsuzaki, Shigeki Inui

dermal papilla cell-derived extracellular vesicles DPC-EVs adipose-derived stem cells ASCs β-catenin activation hair inductive gene expression vcan ncam α-sma opn mir-214-5P hair regeneration alopecia extracellular vesicles stem cells beta-catenin hair loss hair growth

TLDR Dermal papilla cell vesicles can boost hair growth genes in fat stem cells.

The study demonstrates that dermal papilla cell-derived extracellular vesicles (DPC-EVs) significantly enhance hair inductive gene expression in adipose-derived stem cells (ASCs) via β-catenin activation. DPC-EVs were shown to be biologically active and capable of being uptaken by ASCs, leading to increased expression of hair-related genes such as vcan, ncam, α-sma, and opn. The study highlights the potential of DPC-EVs, particularly those with lower levels of mir-214-5P, as a promising therapeutic tool for hair regeneration and treating hair loss conditions like alopecia. Further research is needed to fully understand their therapeutic potential.

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Research cited in this study

13 / 13 results

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Extracellular Vesicles From 3D Cultured Dermal Papilla Cells Improve Wound Healing Via Krüppel-Like Factor 4/Vascular Endothelial Growth Factor A-Driven Angiogenesis

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Dermal Papilla Cell-Derived Extracellular Vesicles Increase Hair Inductive Gene Expression in Adipose Stem Cells via β-Catenin Activation

Research cited in this study

research Neural Progenitor Cell-Derived Nanovesicles Promote Hair Follicle Growth via miR-100

research Dermal Exosomes Containing miR-218-5p Promote Hair Regeneration by Regulating β-Catenin Signaling

research Optimal Stimulation Toward the Dermal Papilla Lineage Can Be Promoted by Combined Use of Osteogenic and Adipogenic Inducers

research Activation of Wnt/β-Catenin Signaling Is Involved in Hair Growth-Promoting Effect of 655-nm Red Light and LED in In Vitro Culture Model

research miR-195-5p Regulates Hair Follicle Inductivity of Dermal Papilla Cells by Suppressing Wnt/β-Catenin Activation

research Extracellular Vesicles Derived from MSCs Activate Dermal Papilla Cells In Vitro and Promote Hair Follicle Conversion from Telogen to Anagen in Mice

research Fibroblast Growth Factors Stimulate Hair Growth Through Beta-Catenin and Shh Expression in C57BL/6 Mice

research MicroRNA-214 Controls Skin and Hair Follicle Development by Modulating the Activity of the Wnt Pathway

research Prospect of Stem Cell Conditioned Medium in Regenerative Medicine

research Therapeutic Strategy for Hair Regeneration: Hair Cycle Activation, Niche Environment Modulation, Wound-Induced Follicle Neogenesis, and Stem Cell Engineering

research Pattern Hair Loss in Men: Diagnosis, Genetic Link, Clinical Features, and Treatments

research Adipocyte Lineage Cells Contribute to the Skin Stem Cell Niche to Drive Hair Cycling

research Osteopontin Gene Is Expressed in the Dermal Papilla of Pelage Follicles in a Hair-Cycle-Dependent Manner

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