Dermal Papilla Cell-Derived Extracellular Vesicles Increase Hair Inductive Gene Expression in Adipose Stem Cells via β-Catenin Activation

January 2022 in “ Cells ”

Taheruzzaman Kazi, Abir Nagata, Takatoshi Nakagawa, Takashi Matsuzaki, Shigeki Inui

dermal papilla cell-derived extracellular vesicles DPC-EVs adipose-derived stem cells ASCs β-catenin activation hair inductive gene expression vcan ncam α-sma opn mir-214-5P hair regeneration alopecia extracellular vesicles stem cells beta-catenin hair loss hair growth

TLDR Dermal papilla cell vesicles can boost hair growth genes in fat stem cells.

The study demonstrates that dermal papilla cell-derived extracellular vesicles (DPC-EVs) significantly enhance hair inductive gene expression in adipose-derived stem cells (ASCs) via β-catenin activation. DPC-EVs were shown to be biologically active and capable of being uptaken by ASCs, leading to increased expression of hair-related genes such as vcan, ncam, α-sma, and opn. The study highlights the potential of DPC-EVs, particularly those with lower levels of mir-214-5P, as a promising therapeutic tool for hair regeneration and treating hair loss conditions like alopecia. Further research is needed to fully understand their therapeutic potential.

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research Neural Progenitor Cell-Derived Nanovesicles Promote Hair Follicle Growth via miR-100

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research Dermal Exosomes Containing miR-218-5p Promote Hair Regeneration by Regulating β-Catenin Signaling

65 citations , July 2020 in “Science Advances”

Dermal exosomes with miR-218-5p boost hair growth by controlling β-catenin signaling.

research Optimal Stimulation Toward the Dermal Papilla Lineage Can Be Promoted by Combined Use of Osteogenic and Adipogenic Inducers

2 citations , December 2019 in “FEBS open bio”

Combining specific inducers helps dermal papilla cells regain hair-forming ability.

research Activation of Wnt/β-Catenin Signaling Is Involved in Hair Growth-Promoting Effect of 655-nm Red Light and LED in In Vitro Culture Model

19 citations , February 2018 in “Lasers in Medical Science”

Red light and LED treatments help hair grow by activating a specific cell signaling pathway.

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19 citations , January 2018 in “BioMed Research International”

miR-195-5p reduces hair growth ability in cells by blocking a specific growth signal.

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113 citations , November 2017 in “Scientific Reports”

Tiny particles from stem cells help activate hair growth cells and encourage hair growth in mice without being toxic.

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103 citations , November 2014 in “Journal of Cell Biology”

MicroRNA-214 is important for skin and hair growth because it affects the Wnt pathway.

research Prospect of Stem Cell Conditioned Medium in Regenerative Medicine

298 citations , January 2014 in “BioMed Research International”

Stem cell-derived conditioned medium shows promise for treating various medical conditions but requires standardized production and further validation.

research Therapeutic Strategy for Hair Regeneration: Hair Cycle Activation, Niche Environment Modulation, Wound-Induced Follicle Neogenesis, and Stem Cell Engineering

74 citations , January 2013 in “Expert Opinion on Biological Therapy”

The conclusion is that hair growth can be improved by activating hair cycles, changing the surrounding environment, healing wounds to create new hair follicles, and using stem cell technology.