Alterations in Pattern Baldness According to Sex: Hair Metabolomics Approach

March 2021 in “ Metabolites ”

Yu Ra Lee, Bark Lynn Lew, Woo Young Sim, Jongki Hong, Bong Chul Chung

pattern baldness steroid hormone biosynthesis androgen metabolism testosterone dihydrotestosterone estrogen hormones arachidonic acid metabolism inflammation DHT

TLDR Hair loss causes differ between men and women due to changes in hormone levels and inflammation-related pathways.

The study "Alterations in Pattern Baldness According to Sex: Hair Metabolomics Approach" analyzed 140 human hair samples to identify metabolic alterations in pattern baldness patients, with a focus on sex differences. The most significantly altered pathway was steroid hormone biosynthesis in both males and females. In males, androgen metabolism was significantly altered, with lower testosterone levels and higher dihydrotestosterone levels. In females, changes were observed in estrogen hormones and their metabolites, and the arachidonic acid metabolism pathways, which are related to inflammation, were altered. This study suggests that the causes of hair loss differ according to sex and further research is needed to understand the correlation between pattern baldness and various metabolites according to sex.

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research Alterations in Pattern Baldness According to Sex: Hair Metabolomics Approach

3 citations , March 2021 in “Metabolites”

Hair loss causes differ between men and women due to changes in hormone levels and inflammation-related pathways.