The Efficacy and Safety of 17α-Estradiol (Ell-Cranell Alpha 0.025%) Solution on Female Pattern Hair Loss: Single Center, Open-Label, Non-Comparative, Phase IV Study

January 2012 in “ Annals of Dermatology ”

Jae-Hong Kim, Sung Koo Lee, Hae Young Lee, Na Young Yoon, Won Young Lee

17α-Estradiol Ell-Cranell alpha 0.025% female pattern hair loss hair density hair thickness phototrichogram Ell-Cranell

Studysummary This study reported that Ell-Cranell® alpha 0.025% solution significantly increased hair counts and diameter in Korean women with female pattern hair loss over an 8-month period, showing both efficacy and safety.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

This document is a compilation of several studies that evaluated the efficacy and safety of 17α-Estradiol (Ell-Cranell® alpha 0.025%) solution on female pattern hair loss. The studies involved a total of 253 female patients who applied the drug for eight months. The results showed that the drug was effective in improving hair density and hair thickness, as assessed by phototrichogram, and was well-tolerated with no serious adverse events reported. The studies concluded that 17α-estradiol solution is a safe and effective treatment option for female pattern hair loss.

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Research cited in this study

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research A New Classification of Pattern Hair Loss That Is Universal for Men and Women: Basic and Specific (BASP) Classification

125 citations , May 2007 in “Journal of The American Academy of Dermatology”

This study describes the development of the BASP classification system, providing a universal and systematic approach for classifying pattern hair loss in both men and women.

Comparison of the Efficacy and Safety of Topical Minoxidil and Topical Alfatradiol in the Treatment of Androgenetic Alopecia in Women

research Comparison of the Efficacy and Safety of Topical Minoxidil and Topical Alfatradiol in the Treatment of Androgenetic Alopecia in Women

56 citations , April 2007 in “Journal der Deutschen Dermatologischen Gesellschaft”

This study found that 12 months of minoxidil treatment increased hair density and thickness in women with androgenetic alopecia, while alfatradiol primarily stabilized hair loss.

research Alfatradiol (0.025%) - An Effective and Safe Treatment Option for Androgenetic Alopecia in Women and Men

10 citations , December 2005 in “Aktuelle Dermatologie”

This study reported that after 7.5 months of treatment, topical Alfatradiol significantly increased anagen hair rates in women and men with androgenetic alopecia, with minimal side effects.

research Treatment of Female Pattern Hair Loss With Oral Antiandrogens

179 citations , March 2005 in “British Journal of Dermatology”

This study found that 88% of women with female pattern hair loss who received oral antiandrogens saw no progression or improvement in their condition.

research Androgen Action on Human Skin – From Basic Research to Clinical Significance

147 citations , October 2004 in “Experimental dermatology”

This paper reviews the role of androgens in human skin function and the challenges in developing treatments for androgen-associated disorders, reporting no new experimental results.

research A Randomized, Placebo-Controlled Trial of 5% and 2% Topical Minoxidil Solutions in the Treatment of Female Pattern Hair Loss

219 citations , March 2004 in “Journal of The American Academy of Dermatology”

In this 48-week trial, 5% topical minoxidil was more effective than both 2% minoxidil and placebo in promoting hair growth in women with female pattern hair loss, with notable improvements in nonvellus hair count and hair growth assessments.

research Decreased Serum Ferritin Is Associated With Alopecia in Women

163 citations , November 2003 in “Journal of Investigative Dermatology”

This study found that women with androgenetic alopecia or alopecia areata have significantly lower serum ferritin levels than those without hair loss, suggesting a potential link between these types of alopecia and decreased iron stores.

research Testosterone Metabolism in Human Skin Cells In Vitro and Its Interaction with Estradiol and Dutasteride

21 citations , January 2003 in “Skin pharmacology and physiology”

This study found that dutasteride completely suppressed the formation of 5alpha-dihydro metabolites in cultured human skin cells, suggesting its potential use in acne and androgenetic alopecia.

research Steroidogenic Isoenzymes in Human Hair and Their Potential Role in Androgenetic Alopecia

31 citations , January 2003 in “Dermatology”

This article provides an overview of recent discoveries about steroidogenic enzymes involved in androgenetic alopecia but reports no new clinical results.

research 17α-Estradiol Induces Aromatase Activity in Intact Human Anagen Hair Follicles Ex Vivo

94 citations , August 2002 in “Experimental Dermatology”

This study found that 17α‐estradiol increases aromatase activity in female hair follicles, which may explain its beneficial effects in treating androgenetic alopecia.

research The Prevalence and Types of Androgenetic Alopecia in Korean Men and Women

157 citations , July 2001 in “British Journal of Dermatology”

In this study, the prevalence of androgenetic alopecia among Korean men and women was found to be lower than in caucasians, with Korean men showing more frontal hairline preservation and a higher incidence of 'female pattern' hair thinning.

research Fortnightly Review: Male Pattern Androgenetic Alopecia

179 citations , September 1998 in “BMJ”

This article reviews the pathogenesis, genetic basis, and recent treatment breakthroughs for androgenetic alopecia but reports no new clinical findings.

Different Levels of 5α-Reductase Type I and II, Aromatase, and Androgen Receptor in Hair Follicles of Women and Men with Androgenetic Alopecia

research Different Levels of 5α-Reductase Type I and II, Aromatase, and Androgen Receptor in Hair Follicles of Women and Men with Androgenetic Alopecia

416 citations , September 1997 in “Journal of Investigative Dermatology”

People with hair loss have more androgen receptors and enzymes in certain follicles, with men and women showing different patterns.

research Patterned Androgenic Alopecia in Women

130 citations , May 1988 in “Journal of The American Academy of Dermatology”

This study found that frontal and frontoparietal hair recession is relatively common in women, especially after menopause, and may not indicate abnormal androgen metabolism absent other virilization signs.

research Local Therapy of Androgenetic Alopecia with 17α-Estradiol

54 citations , January 1980 in “Dermatology”

This study found that topical application of hair lotion containing 17α-estradiol may reduce androgenetic hair loss, as 63% of treated patients showed a decrease in telogen hairs compared to 37% in the control group.