Distribution of Polyamines May Be Altered in Different Scalp Regions of Patients with Hair Loss

In a 2019 study by Yu Ra Lee et al., the distribution of polyamines in scalp regions of 48 patients with hair loss was examined using liquid chromatography-mass spectrometry. The study included equal numbers of male and female patients suffering from male-pattern baldness (MPB) and female-pattern hair loss (FPHL). The findings revealed that polyamine levels were generally higher in the vertex region than in the occipital region, with significant differences in N-acetyl polyamine levels. This suggests that polyamine distribution may play a role in the development of MPB and FPHL, and that N-acetyl polyamines could be a potential marker for androgenic alopecia research. The research also highlighted a non-invasive method for collecting hair samples to study baldness patterns.