Germination Enhances Phytochemical Profiles of Perilla Seeds and Promotes Hair Growth via 5α-Reductase Inhibition and Growth Factor Pathways
July 2025
in “
Biology
”
Perilla frutescens germinated perilla seeds supercritical fluid extraction 5α-reductase inhibition growth factor pathways polyphenols fatty acids hair follicle cell proliferation antioxidant properties anti-inflammatory properties oxidative stress androgenetic alopecia gene expression hair growth-related genes bioactive compounds perilla seed extracts SFE 5-alpha-reductase hair growth pathways hair follicle growth natural hair loss treatment
TLDR Germinated perilla seeds can naturally promote hair growth and prevent hair loss.
The study found that germinated Perilla frutescens seed extracts, particularly those obtained through supercritical fluid extraction (SFE), significantly promote hair growth and prevent hair loss. The extracts were rich in bioactive compounds like polyphenols and fatty acids, which enhanced hair follicle cell proliferation and migration. They demonstrated antioxidant and anti-inflammatory properties, reduced oxidative stress, and suppressed the expression of genes involved in androgenetic alopecia more effectively than standard treatments like finasteride and minoxidil. Additionally, the extracts upregulated hair growth-related genes, suggesting that germinated perilla seeds could be a promising natural treatment for hair loss. However, the study does not specify the number of participants involved.
