Comparison of In Vitro Hair Growth Promotion and Anti-Hair Loss Potential of Thai Rice By-Product from Oryza Sativa L. Cv. Buebang 3 CMU and Sanpatong

November 2024 in “ Plants ”

Anurak Muangsanguan, Warintorn Ruksiriwanich, Chaiwat Arjin, Sansanee Jamjod, Chanakan Prom‐u‐thai, Pensak Jantrawut, Pornchai Rachtanapun, Patipan Hnorkaew, Apinya Sartsook, Mathukorn Sainakham, Juan Manuel Castagnini, Korawan Sringarm

rice bran extract Buebang 3 CMU Sanpatong ethanolic extract γ-oryzanol tocopherols antioxidant anti-inflammatory human hair follicle dermal papilla cells Wnt/β-catenin Sonic Hedgehog minoxidil finasteride rice bran Et-BB3-CMU

TLDR Et-BB3-CMU rice bran extract may be a promising natural option for promoting hair growth and preventing hair loss.

This study evaluates the hair growth promotion and anti-hair loss potential of rice bran extracts from Thai rice varieties Buebang 3 CMU and Sanpatong. The ethanolic extract of Buebang 3 CMU (Et-BB3-CMU) showed superior results, with high levels of bioactive compounds like γ-oryzanol and tocopherols, significant antioxidant and anti-inflammatory activities, and enhanced proliferation of human hair follicle dermal papilla cells. It effectively activated hair growth signaling pathways, such as Wnt/β-catenin and Sonic Hedgehog, and suppressed hair loss-related pathways more than standard treatments like minoxidil and finasteride. These findings suggest that Et-BB3-CMU could be a promising natural alternative for hair growth and hair loss prevention.

View this study on mdpi.com →

Discuss this study in the Community →

Research cited in this study

25 / 25 results

research Hair Growth Promotion and Anti-Hair Loss Effects of Arabica Coffee Pulp Extracts Using Supercritical Fluid Extraction

November 2023 in “Foods”

Arabica coffee pulp extract may help prevent hair loss and promote hair growth.

research Regulatory Effects of Thai Rice By-Product Extracts from Oryza Sativa L. Cv. Bue Bang 3 CMU and Bue Bang 4 CMU on Melanin Production, Nitric Oxide Secretion, and Steroid 5α-Reductase Inhibition

1 citations , February 2023 in “Plants”

BB4CMU rice bran oil may help treat hair loss and gray hair.

research Effects of Bioactive Composition in Oryza Sativa L. Cv. KDML105 Bran Extract on Gene Expression Related to Hair Cycle in Human Hair Follicle Dermal Papilla Cells

3 citations , January 2023 in “Agronomy”

KDML105 bran extract may help with hair growth and prevent hair loss.

Bioactive Metabolites of Edible Mushrooms Efficacious Against Androgenic Alopecia: Targeting SRD5A2 Using Computational Approach

research Bioactive Metabolites of Edible Mushrooms Efficacious Against Androgenic Alopecia: Targeting SRD5A2 Using Computational Approach

November 2022 in “Journal of Herbal Medicine”

Certain compounds found in edible mushrooms may help treat hair loss.

research Comparison of Oral Minoxidil, Finasteride, and Dutasteride for Treating Androgenetic Alopecia

1 citations , August 2022 in “Journal of Dermatological Treatment”

Dutasteride is the most effective for hair loss but may cause sexual and mental side effects.

research Phytochemical Constitution, Anti-Inflammation, Anti-Androgen, and Hair Growth-Promoting Potential of Shallot (Allium Ascalonicum L.) Extract

9 citations , June 2022 in “Plants”

Shallot extract may help with hair growth and treating hair loss.

Cyanidin 3-O-Arabinoside Suppresses DHT-Induced Dermal Papilla Cell Senescence by Modulating p38-Dependent ER-Mitochondria Contacts

research Cyanidin 3-O-Arabinoside Suppresses DHT-Induced Dermal Papilla Cell Senescence by Modulating p38-Dependent ER-Mitochondria Contacts

14 citations , March 2022 in “Journal of Biomedical Science”

Cyanidin 3-O-arabinoside may help treat a common form of hair loss by protecting cells against aging and improving cell function.

Antioxidation, Anti-Inflammation, and Regulation of SRD5A Gene Expression of Oryza Sativa cv. Bue Bang 3 CMU Husk and Bran Extracts as Androgenetic Alopecia Molecular Treatment Substances

research Antioxidation, Anti-Inflammation, and Regulation of SRD5A Gene Expression of Oryza Sativa cv. Bue Bang 3 CMU Husk and Bran Extracts as Androgenetic Alopecia Molecular Treatment Substances

7 citations , January 2022 in “Plants”

Rice husk and bran extracts from the Bue Bang 3 CMU variety can potentially treat hair loss due to their antioxidant, anti-inflammatory, and anti-androgenic properties.

Physical Stability and Subjective Efficacy Study of Liposome Loaded with Clitoria Ternatea (Butterfly Pea) Flower Extract and Eugenia Caryophyllus (Clove) Oil

research Physical Stability and Subjective Efficacy Study of Liposome Loaded with Clitoria Ternatea (Butterfly Pea) Flower Extract and Eugenia Caryophyllus (Clove) Oil

January 2022 in “Pharmaceutical Sciences Asia”

Liposomes with butterfly pea extract and clove oil are stable and effective according to users.

research Lasers, Lights, and Compounds for Hair Loss in Aesthetics

3 citations , August 2021 in “Clinics in Dermatology”

Minoxidil is the main over-the-counter treatment for hair loss, with other options like finasteride, latanoprost, retinoic acid, antioxidants, biotin, nutraceuticals, and platelet-rich plasma therapy also showing promise.

research Effects on Steroid 5-Alpha Reductase Gene Expression of Thai Rice Bran Extracts and Molecular Dynamics Study on SRD5A2

14 citations , April 2021 in “Biology”

Thai rice bran extracts, especially from Tubtim Chumphae rice, can significantly reduce the activity of hair loss genes, with x-tocopherol showing potential as an anti-hair loss product.

Observation of the Expression of Vascular Endothelial Growth Factor and the Potential Effect of Promoting Hair Growth Treated with Chinese Herbal BeauTop

research Observation of the Expression of Vascular Endothelial Growth Factor and the Potential Effect of Promoting Hair Growth Treated with Chinese Herbal BeauTop

3 citations , February 2021 in “Evidence-based Complementary and Alternative Medicine”

The Chinese herbal supplement BeauTop can potentially boost hair growth and thickness by increasing a protein called Vascular Endothelial Growth Factor.

research Review of Hair Follicle Dermal Papilla Cells as In Vitro Screening Model for Hair Growth

76 citations , August 2018 in “International Journal of Cosmetic Science”

Dermal Papilla cells are a promising tool for evaluating hair growth treatments.

research Minoxidil Promotes Hair Growth Through Stimulation of Growth Factor Release from Adipose-Derived Stem Cells

42 citations , February 2018 in “International Journal of Molecular Sciences”

Minoxidil boosts hair growth by triggering growth factor release from specific stem cells.

research The Study of Growth Factors in Patients with Androgenic Alopecia

7 citations , September 2017 in “Biomedical and Pharmacology Journal”

Growth factors greatly affect hair loss, with different levels seen in men, women, younger patients, and at the start of the condition.

research The Role of Macrophages in Skin Homeostasis

65 citations , February 2017 in “Pflügers Archiv - European Journal of Physiology”

Macrophages are vital for skin healing, hair growth, salt balance, and cancer defense.

research Mechanism of Action of Herbs and Their Active Constituents Used in Hair Loss Treatment

47 citations , August 2016 in “Fitoterapia”

Some herbs and their components might help treat hair loss by affecting various biological pathways, but more research and regulation are needed.

research Collagenase IV Plays an Important Role in Regulating Hair Cycle by Inducing VEGF, IGF-1, and TGF-Beta Expression

27 citations , September 2015 in “Drug Design Development and Therapy”

research Oxidative Stress-Associated Senescence in Dermal Papilla Cells of Men with Androgenetic Alopecia

93 citations , February 2015 in “Journal of Investigative Dermatology”

Oxidative stress affects hair loss in men with androgenetic alopecia.

research Effectiveness of the Combinational Treatment of Laminaria Japonica and Cistanche Tubulosa Extracts in Hair Growth

9 citations , January 2015 in “Laboratory Animal Research”

Laminaria japonica and Cistanche tubulosa extracts combined may effectively promote hair growth.

research Coordinated Activation of Wnt in Epithelial and Melanocyte Stem Cells Initiates Pigmented Hair Regeneration

260 citations , June 2011 in “Cell”

Wnt signaling is crucial for pigmented hair regeneration by controlling stem cell activation and differentiation.

research Dihydrotestosterone-Inducible Dickkopf 1 from Balding Dermal Papilla Cells Causes Apoptosis in Follicular Keratinocytes

171 citations , July 2007 in “Journal of Investigative Dermatology”

A substance called DKK-1 increases in balding areas and causes hair cells to die when exposed to DHT.

The Importance of Dual 5α-Reductase Inhibition in the Treatment of Male Pattern Hair Loss: Results of a Randomized Placebo-Controlled Study of Dutasteride Versus Finasteride

research The Importance of Dual 5α-Reductase Inhibition in the Treatment of Male Pattern Hair Loss: Results of a Randomized Placebo-Controlled Study of Dutasteride Versus Finasteride

215 citations , November 2006 in “Journal of The American Academy of Dermatology”

Dutasteride more effective for hair growth, but has more side effects than finasteride.

research Molecular Principles of Hair Follicle Induction and Morphogenesis

479 citations , January 2005 in “BioEssays”

Hair follicle development is controlled by interactions between skin tissues and specific molecular signals.

research Molecular Mechanisms of Androgenetic Alopecia

229 citations , August 2002 in “Experimental Gerontology”

AGA causes hair loss by shrinking hair follicles due to DHT binding, and can be treated with finasteride and minoxidil.

Similar Research

5 / 962 results

research Novel Strategies for Androgenetic Alopecia Therapy: Integrating Multifunctional Plant Extracts with Nanotechnology for Advanced Cutaneous Drug Delivery

September 2025 in “Pharmaceutics”

Combining plant extracts with nanotechnology may improve hair loss treatments.

research Anti-Hair Loss Potential of Perilla Seed Extracts: In Vitro Molecular Insights from Supercritical Fluid Extraction

July 2025 in “Foods”

Perilla seed extract may help prevent hair loss better than some standard treatments.

Germination Enhances Phytochemical Profiles of Perilla Seeds and Promotes Hair Growth via 5α-Reductase Inhibition and Growth Factor Pathways

research Germination Enhances Phytochemical Profiles of Perilla Seeds and Promotes Hair Growth via 5α-Reductase Inhibition and Growth Factor Pathways

July 2025 in “Biology”

Germinated perilla seeds can naturally promote hair growth and prevent hair loss.

research Antioxidation, Anti-Inflammation, and Regulation of SRD5A Gene Expression of Oryza Sativa cv. Bue Bang 3 CMU Husk and Bran Extracts as Androgenetic Alopecia Molecular Treatment Substances

7 citations , January 2022 in “Plants”

Rice husk and bran extracts from the Bue Bang 3 CMU variety can potentially treat hair loss due to their antioxidant, anti-inflammatory, and anti-androgenic properties.

research Regulatory Effects of Thai Rice By-Product Extracts from Oryza Sativa L. Cv. Bue Bang 3 CMU and Bue Bang 4 CMU on Melanin Production, Nitric Oxide Secretion, and Steroid 5α-Reductase Inhibition

1 citations , February 2023 in “Plants”

BB4CMU rice bran oil may help treat hair loss and gray hair.

Comparison of In Vitro Hair Growth Promotion and Anti-Hair Loss Potential of Thai Rice By-Product from Oryza Sativa L. Cv. Buebang 3 CMU and Sanpatong

Research cited in this study

research Hair Growth Promotion and Anti-Hair Loss Effects of Arabica Coffee Pulp Extracts Using Supercritical Fluid Extraction

research Regulatory Effects of Thai Rice By-Product Extracts from Oryza Sativa L. Cv. Bue Bang 3 CMU and Bue Bang 4 CMU on Melanin Production, Nitric Oxide Secretion, and Steroid 5α-Reductase Inhibition

research Effects of Bioactive Composition in Oryza Sativa L. Cv. KDML105 Bran Extract on Gene Expression Related to Hair Cycle in Human Hair Follicle Dermal Papilla Cells

research Bioactive Metabolites of Edible Mushrooms Efficacious Against Androgenic Alopecia: Targeting SRD5A2 Using Computational Approach

research Comparison of Oral Minoxidil, Finasteride, and Dutasteride for Treating Androgenetic Alopecia

research Phytochemical Constitution, Anti-Inflammation, Anti-Androgen, and Hair Growth-Promoting Potential of Shallot (Allium Ascalonicum L.) Extract

research Cyanidin 3-O-Arabinoside Suppresses DHT-Induced Dermal Papilla Cell Senescence by Modulating p38-Dependent ER-Mitochondria Contacts

research Antioxidation, Anti-Inflammation, and Regulation of SRD5A Gene Expression of Oryza Sativa cv. Bue Bang 3 CMU Husk and Bran Extracts as Androgenetic Alopecia Molecular Treatment Substances

research Physical Stability and Subjective Efficacy Study of Liposome Loaded with Clitoria Ternatea (Butterfly Pea) Flower Extract and Eugenia Caryophyllus (Clove) Oil

research Lasers, Lights, and Compounds for Hair Loss in Aesthetics

research Effects on Steroid 5-Alpha Reductase Gene Expression of Thai Rice Bran Extracts and Molecular Dynamics Study on SRD5A2

research Observation of the Expression of Vascular Endothelial Growth Factor and the Potential Effect of Promoting Hair Growth Treated with Chinese Herbal BeauTop

research Review of Hair Follicle Dermal Papilla Cells as In Vitro Screening Model for Hair Growth

research Minoxidil Promotes Hair Growth Through Stimulation of Growth Factor Release from Adipose-Derived Stem Cells

research The Study of Growth Factors in Patients with Androgenic Alopecia

research The Role of Macrophages in Skin Homeostasis

research Mechanism of Action of Herbs and Their Active Constituents Used in Hair Loss Treatment

research Collagenase IV Plays an Important Role in Regulating Hair Cycle by Inducing VEGF, IGF-1, and TGF-Beta Expression

research Oxidative Stress-Associated Senescence in Dermal Papilla Cells of Men with Androgenetic Alopecia

research Effectiveness of the Combinational Treatment of Laminaria Japonica and Cistanche Tubulosa Extracts in Hair Growth

research Coordinated Activation of Wnt in Epithelial and Melanocyte Stem Cells Initiates Pigmented Hair Regeneration

research Dihydrotestosterone-Inducible Dickkopf 1 from Balding Dermal Papilla Cells Causes Apoptosis in Follicular Keratinocytes

research The Importance of Dual 5α-Reductase Inhibition in the Treatment of Male Pattern Hair Loss: Results of a Randomized Placebo-Controlled Study of Dutasteride Versus Finasteride

research Molecular Principles of Hair Follicle Induction and Morphogenesis

research Molecular Mechanisms of Androgenetic Alopecia

Related Community Posts Join

community What About Phytosterol Alternatives - Rice Bran Oil - Natural DHT Blockers

community Rice bran as effective in promoting hair growth as medical drug minoxidil.

community White Rice Lowers DHT and might cause post finasteride syndrome

community Fermented Rice Water ..... ???

community Life Extension - Hair Growth for Men

community 200 days hair regrowth . Seeing some growth

Similar Research

research Novel Strategies for Androgenetic Alopecia Therapy: Integrating Multifunctional Plant Extracts with Nanotechnology for Advanced Cutaneous Drug Delivery

research Anti-Hair Loss Potential of Perilla Seed Extracts: In Vitro Molecular Insights from Supercritical Fluid Extraction

research Germination Enhances Phytochemical Profiles of Perilla Seeds and Promotes Hair Growth via 5α-Reductase Inhibition and Growth Factor Pathways

research Antioxidation, Anti-Inflammation, and Regulation of SRD5A Gene Expression of Oryza Sativa cv. Bue Bang 3 CMU Husk and Bran Extracts as Androgenetic Alopecia Molecular Treatment Substances

research Regulatory Effects of Thai Rice By-Product Extracts from Oryza Sativa L. Cv. Bue Bang 3 CMU and Bue Bang 4 CMU on Melanin Production, Nitric Oxide Secretion, and Steroid 5α-Reductase Inhibition