Wound Healing Effect of Supercritical Carbon Dioxide Datura Metel L. Leaves Extracts: An In Vitro Study of Anti-Inflammation, Cell Migration, MMP-2 Inhibition, and the Modulation of the Sonic Hedgehog Pathway in Human Fibroblasts

July 2023 in “ Plants ”

Warintorn Ruksiriwanich, Pichchapa Linsaenkart, Anurak Muangsanguan, Korawan Sringarm, Pensak Jantrawut, Chaiwat Arjin, Sarana Rose Sommano, Yuthana Phimolsiripol, Francisco J. Barba

Datura metel supercritical carbon dioxide extraction Dm1 Dm2 antioxidant anti-inflammatory cell migration sonic hedgehog pathway MMP-2 inhibition human fibroblasts scCO2 extraction

TLDR Datura metel leaf extracts help heal wounds effectively.

This study explores the wound healing properties of Datura metel L. leaves extracts (Dm1 and Dm2) using supercritical carbon dioxide extraction. The extracts exhibited significant antioxidant and anti-inflammatory activities, comparable to l-ascorbic acid, and effectively inhibited nitrite production. Dm1 showed notable wound closure rates, similar to commercial treatments, and both extracts suppressed MMP-2 expression, supporting collagen production. They also upregulated genes in the sonic hedgehog pathway, crucial for cell migration and wound healing. The presence of bioactive compounds like farnesyl acetone, schisanhenol, and loliolide contributes to these effects, suggesting that D. metel extracts could be a promising natural treatment for wound healing.

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