Antioxidant Natural Plant Constituents For Diabetic Wound Repair

The document explores the potential of antioxidant natural plant constituents, such as polyphenols and flavonoids, in promoting diabetic wound repair by addressing oxidative stress, inflammation, and infections. These compounds, including resveratrol, epigallocatechin gallate, and quercetin, enhance wound healing through mechanisms like scavenging reactive oxygen species, regulating inflammatory pathways, and exhibiting antibacterial properties. They promote cell proliferation, angiogenesis, and tissue regeneration, offering advantages over synthetic drugs due to their multi-target effects and low toxicity. Despite challenges like low bioavailability, combining these antioxidants with biomaterials shows promise in enhancing their delivery and efficacy. The study underscores the need for further research into delivery systems and clinical applications to optimize treatment for diabetic wounds.