Hydrogel Film Sheets-Based Medicinal Plants for Diabetic Wound Dressing Application: A Review

This review discusses the development and properties of hydrogel films made from medicinal plants for use in diabetic wound dressings. Hydrogel films are favored for their ability to protect wounds, promote fibroblast proliferation, and minimize fluid loss. The review highlights the significant effects of medicinal plant extracts, such as Curcuma longa Linn, Aloe vera, Embelia ribes, Ulmus davidiana, Mentha piperita, Centella asiatica, and Garcinia mangostana, in wound healing. These extracts have been shown to increase the expression of vascular endothelial growth factor (VEGF) and transforming growth factor-β (TGF-β), which are crucial for stimulating wound healing processes like re-epithelialization, angiogenesis, granulation tissue formation, and collagen fiber deposition. The review concludes that medicinal plants are valuable for the development of future diabetic wound dressing treatments.