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research Wound Healing Effect of Supercritical Carbon Dioxide Datura Metel L. Leaves Extracts: An In Vitro Study of Anti-Inflammation, Cell Migration, MMP-2 Inhibition, and the Modulation of the Sonic Hedgehog Pathway in Human Fibroblasts

6 citations , July 2023 in “Plants”

This study investigates the wound healing properties of Datura metel L. leaf extracts obtained through supercritical carbon dioxide extraction. The extracts, Dm1 and Dm2, were analyzed for their phytochemical profiles and biological activities, including antioxidant and anti-inflammatory effects, cell migration, and modulation of the sonic hedgehog pathway in human fibroblasts. Both extracts demonstrated antioxidant properties comparable to l-ascorbic acid and significantly inhibited nitrite production. Dm1 showed notable wound closure rates of 58.46% and 82.62% after 36 and 48 hours, respectively, similar to commercial treatments. Additionally, both extracts suppressed MMP-2 expression, and Dm1 upregulated genes in the sonic hedgehog pathway, suggesting that the scCO2 extraction technique could enhance D. metel's potential for effective wound healing.

research Cellular Senescence and Aging in Myotonic Dystrophy

4 citations , February 2022 in “International Journal of Molecular Sciences”

Myotonic Dystrophy may age cells faster, and drugs that target aging could be potential treatments.

research Screening for Abnormal Glucose Metabolism in Adolescents with Polycystic Ovary Syndrome

March 2012 in “Journal of Pediatric and Adolescent Gynecology”

Teens with PCOS have a higher risk of type 2 diabetes and need regular glucose checks.

research Cutaneous Features of Myotonic Dystrophy Types 1 and 2: Implications of Premature Aging and Vitamin D Homeostasis

18 citations , November 2016 in “Neuromuscular Disorders”

Patients with myotonic dystrophy often have skin problems that suggest early aging and vitamin D issues, and the severity of these problems is linked to their genetic condition and vitamin D levels.

research Hair Follicle Characteristics as Early Marker of Type 2 Diabetes

13 citations , August 2016 in “Medical Hypotheses”

Hair characteristics might be early signs of Type 2 Diabetes and could help with early prevention.

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community 2.5 months of 1mg fin + 1.25mg OM + dermarolling. Progress or wishful thinking?

in Is this regrowth? 203 upvotes 2 years ago

A user's 2.5 months of finasteride, oral minoxidil, and dermarolling treatments for hair loss, with various users giving their opinion on the progress made.