Cellular Senescence and Aging in Myotonic Dystrophy

February 2022 in “ International Journal of Molecular Sciences ”

Yuhei Hasuike, Hidetaka Mochizuki, Mikihito Nakamori

myotonic dystrophy DM1 DM2 CTG repeats CCTG repeats nuclear foci RNA-binding proteins alternative splicing dysregulation cellular senescence androgenetic alopecia dermal papilla cells senolytics senomorphics androgenic alopecia balding DPCs

Studysummary This review discusses the similarities between myotonic dystrophy and aging, highlighting the role of cellular senescence in its pathophysiology, and reports no new clinical findings; the authors note potential anti-aging therapy applications.

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