Application of Non-Pharmacologic Therapy in Hair Loss Treatment and Hair Regrowth

July 2024 in “ Clinical Cosmetic and Investigational Dermatology ”

Xinlyu Huang, Pengxiang Zhao, Gongjie Zhang, Xiaoli Su, Hanlin Li, Huizi Gong, Xuemei Ma, Fang Liu

hydrogen therapy hyperbaric oxygen therapy platelet-rich plasma low-level light therapy microneedling regenerative cellular therapies minoxidil HBOT PRP LLLT Rogaine

TLDR Non-drug therapies show promise for hair regrowth but need more research.

The document reviews various non-pharmacologic therapies for treating hair loss and promoting hair regrowth, including hydrogen therapy, hyperbaric oxygen therapy (HBOT), platelet-rich plasma (PRP), low-level light therapy (LLLT), microneedling, and regenerative cellular therapies. These treatments show promise in enhancing hair density, reducing inflammation, and improving the efficacy of topical treatments like minoxidil. However, challenges such as a lack of standardized protocols and limited large-scale studies remain. Further research is needed to confirm their efficacy and establish standardized treatment protocols.

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research Biomimetic Biphasic Microsphere Preparation for Hair Regeneration

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research Autophagy Induces Hair Follicle Stem Cell Activation and Hair Follicle Regeneration by Regulating Glycolysis

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research The Effect of a Helmet-Type, Home-Use Low-Level Light Therapy Device for Chemotherapy-Induced Alopecia: Study Protocol for a Randomized Controlled Trial

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research Assessing The Efficacy Of Monthly 308 Nm Excimer Lamp Double-Stacked Pulse Adjusted Therapy For Alopecia Areata

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Nitric Oxide Synergizes Minoxidil Delivered by Transdermal Hyaluronic Acid Liposomes for Multimodal Androgenetic Alopecia Therapy

research Nitric Oxide Synergizes Minoxidil Delivered by Transdermal Hyaluronic Acid Liposomes for Multimodal Androgenetic Alopecia Therapy

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research Overview of the Circadian Clock in the Hair Follicle Cycle

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research Platelet Rich Plasma Combination Therapies for Treatment of Androgenetic Alopecia: A Systematic Review

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research Randomized Trial of Microneedling Combined With 2% Minoxidil Topical Solution for the Treatment of Female Pattern Hair Loss in a Chinese Population

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research Comparative Study Between Topical Application of Triamcinolone Acetonide After Fractional Carbon Dioxide Laser Versus Microneedling in the Treatment of Resistant Alopecia Areata

October 2022 in “Dermatologic Therapy”

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research Morphogenesis, Growth Cycle, and Molecular Regulation of Hair Follicles

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research Advancing Regenerative Cellular Therapies in Non-Scarring Alopecia

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research Treatment Options for Androgenetic Alopecia: Efficacy, Side Effects, Compliance, Financial Considerations, and Ethics

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research A Systematic Review and Meta-Analysis of Randomized Controlled Trials of United States Food and Drug Administration-Approved, Home-Use, Low-Level Light/Laser Therapy Devices for Pattern Hair Loss: Device Design and Technology

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research Alopecia Areata: An Update on Etiopathogenesis, Diagnosis, and Management

290 citations , August 2021 in “Clinical Reviews in Allergy & Immunology”

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research Minoxidil: A Comprehensive Review

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research Childhood Alopecia Areata: An Overview of Treatment and Recent Patents

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Randomized Trial of Electrodynamic Microneedling Combined with 5% Minoxidil Topical Solution for Treating Androgenetic Alopecia in Chinese Males and Molecular Mechanistic Study of the Involvement of the Wnt/β-Catenin Signaling Pathway

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research Efficacy and Influence Factors of 308-nm Excimer Lamp with Minoxidil in the Treatment of Alopecia Areata

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research Minoxidil And Its Use In Hair Disorders: A Review

117 citations , August 2019 in “Drug Design Development and Therapy”

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research Topical Calcipotriol vs Narrowband Ultraviolet B in Treatment of Alopecia Areata: A Randomized-Controlled Trial

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research Sustained Human Hair Follicle Growth Ex Vivo in a Glycosaminoglycan Hydrogel Matrix

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research Platelet-Rich Plasma as a Treatment for Androgenetic Alopecia

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research Review of Hair Follicle Dermal Papilla Cells as In Vitro Screening Model for Hair Growth

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research Mesenchymal Stem Cells and Stromal Vascular Fraction for Hair Loss

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33 citations , August 2018 in “Facial Plastic Surgery Clinics of North America”

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Efficacy of 1,550-nm Erbium-Glass Fractional Laser Treatment and Its Effect on the Expression of Insulin-Like Growth Factor 1 and Wnt/β-Catenin in Androgenetic Alopecia

research Efficacy of 1,550-nm Erbium-Glass Fractional Laser Treatment and Its Effect on the Expression of Insulin-Like Growth Factor 1 and Wnt/β-Catenin in Androgenetic Alopecia

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research Hair Follicle Growth by Stromal Vascular Fraction-Enhanced Adipose Transplantation in Baldness

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