Biomimetic Biphasic Microsphere Preparation for Hair Regeneration

    February 2024 in “ International Journal of Biological Macromolecules ”
    Yangpeng Chen, Danlan Fu, Xiaoqi Wu … Junfei Huang
    Studysummary In this study, researchers developed a microfluidic-assisted technology to create dual-layer microspheres containing mesenchymal and epidermal cells, which efficiently induced hair follicle regeneration in mice, suggesting potential improvements for hair regeneration treatments in conditions like androgenetic alopecia.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on sciencedirect.com →
    Discuss this study in the Community →

    Research cited in this study 14

    1. EGFR Marks a Subpopulation of Dermal Mesenchymal Cells Highly Expressing IGF1 Which Enhances Hair Follicle Regeneration PubMed · 2023
    2. Hair Follicle Morphogenesis During Embryogenesis, Neogenesis, and Organogenesis Frontiers in Cell and Developmental Biology · 2022
    3. Bioprinting of Hair Follicle Germs for Hair Regenerative Medicine Acta biomaterialia · 2022
    4. Regenerating Hair in Prevascularized Tissue Space Formed by a Controllable Foreign Body Reaction Advanced Functional Materials · 2020
    5. Cellular Nanofiber Structure with Secretory Activity-Promoting Characteristics for Multicellular Spheroid Formation and Hair Follicle Regeneration ACS Applied Materials & Interfaces · 2020
    6. Advances in Regenerative Stem Cell Therapy in Androgenic Alopecia and Hair Loss: Wnt Pathway, Growth Factor, and Mesenchymal Stem Cell Signaling Impact Analysis on Cell Growth and Hair Follicle Development Cells · 2019
    7. Preparation of Hair Beads and Hair Follicle Germs for Regenerative Medicine Biomaterials · 2019
    8. Tissue Engineering of Human Hair Follicles Using a Biomimetic Developmental Approach Nature Communications · 2018
    9. Spontaneous Hair Follicle Germ Formation In Vitro, Enabling The Large-Scale Production Of HFGs For Regenerative Medicine Biomaterials · 2017
    10. Methods for the Isolation and 3D Culture of Dermal Papilla Cells from Human Hair Follicles Experimental Dermatology · 2017
    11. Surface Tension Guided Hanging-Drop: Producing Controllable 3D Spheroids of High-Passaged Human Dermal Papilla Cells and Forming Inductive Microtissues for Hair-Follicle Regeneration ACS Applied Materials & Interfaces · 2016
    12. Large-Scale Cultivation of Transplantable Dermal Papilla Cellular Aggregates Using Microfabricated PDMS Arrays Acta Biomaterialia · 2010
    13. Self-Assembly of Dermal Papilla Cells into Inductive Spheroidal Microtissues on Poly(Ethylene-Co-Vinyl Alcohol) Membranes for Hair Follicle Regeneration Biomaterials · 2008
    14. Isolation and Short-Term Culture of Primary Keratinocytes, Hair Follicle Populations, and Dermal Cells from Newborn Mice and Keratinocytes from Adult Mice for In Vitro Analysis and Grafting to Immunodeficient Mice Nature Protocols · 2008