EGFR Marks a Subpopulation of Dermal Mesenchymal Cells Highly Expressing IGF1 Which Enhances Hair Follicle Regeneration

    May 2023 in “ PubMed ”
    Min Chen, Zaoxu Xu, Yu Chen, Qingyang Yang, Ruiqing Lu, Yankai Dong, Xiaosong Li, Jundong Xie, Ren-He Xu, Haidong Jia, Yan Kang, Yaojiong Wu
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    TLDR A certain type of skin cell, marked by EGFR, produces a lot of IGF1 and helps hair follicles grow back faster.
    The study discovered a group of dermal mesenchymal cells, marked by the epidermal growth factor receptor (EGFR), that express high levels of insulin-like growth factor 1 (IGF1) and boost hair follicle regeneration. These cells were identified in mice using single-cell RNA sequencing data analysis, immunofluorescence staining, and fluorescence-activated cell sorting. The EGFR+ cells showed a higher IGF1 expression level. When IGF1 was applied to wounds in mice, the number of hair follicles in healed wounds increased, suggesting that EGFR+ cells promote wound-induced hair follicle growth. This finding could potentially be used in hair growth treatments.
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