Cell-Laden Gel Biomimetic Skin Promotes Full-Thickness Skin Wound Regeneration

    March 2026 in “ Gels ”
    Pei Zhang, Qianqian Chen, Yuge Pu … Xi Yang
    Studysummary In this study, the researchers developed a biomimetic multilayer composite scaffold combining a decellularized amniotic membrane, fibroblast-laden collagen gel, and epidermal stem cells, which healed full-thickness skin wounds more quickly and effectively by regenerating hair follicles without scarring compared to Moropicin ointment.
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    Research cited in this study 8

    1. Direct Reprogramming of Human Fibroblasts Into Hair-Inducing Dermal Papilla Cell-Like Cells by a Single Small Molecule Biochemical Pharmacology · 2025
    2. Programmable Artificial Skins Achieve Antiscar Healing with Multiple Appendage Regeneration Advanced Materials · 2024
    3. Epidermal Stem Cells: Interplay with the Skin Microenvironment During Wound Healing Molecules and Cells · 2024
    4. Epidermal Stem Cells: Skin Surveillance And Clinical Perspective Journal of Translational Medicine · 2024
    5. Efficient Generation of Skin Organoids from Pluripotent Cells Using Defined Extracellular Matrix Cues and Morphogen Gradients in a Microfluidic Device Advanced healthcare materials/Advanced Healthcare Materials · 2024
    6. Mechanical Forces Across Compartments Coordinate Cell Shape and Fate Transitions to Generate Tissue Architecture Nature cell biology · 2024
    7. P63: A Crucial Player In Epithelial Stemness Regulation Oncogene · 2023
    8. Skinny Fat Cells Stimulate Wound Healing Cell stem cell · 2020