TLDR p63 is essential for controlling epithelial stem cells and tissue health.
The document reviews the role of p63, a key transcription factor, in regulating epithelial stem cell (ESC) activities such as self-renewal, differentiation, and proliferation. p63 is crucial for epithelial tissue homeostasis and development, influencing gene transcription related to cell survival and epithelial-to-mesenchymal transition. The review highlights the diverse effects of p63 isoforms, TAp63 and ΔNp63, in both normal epithelial tissues and epithelium-derived cancers. It also discusses the signaling pathways that modulate these isoforms and their impact on stemness regulation.
5 citations
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January 2022 in “PloS one” Deleting the p63 gene in certain cells causes problems in thymus development and severe hair loss in mice.
29 citations
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October 2016 in “Cell death and differentiation” ΔNp63α stops TAp73β from working in skin cancer by blocking its access to specific genes, not by directly interacting with it.
11 citations
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November 2015 in “Experimental Dermatology” The conclusion is that the IL-6/STAT3 activation affects p63 expression in healing wounds, which may help in hair follicle regeneration.
479 citations
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June 2014 in “Science” Epithelial stem cells can adapt and help in tissue repair and regeneration.
166 citations
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September 2011 in “The Journal of Cell Biology” p63 controls Satb1 to help skin develop properly.
16 citations
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September 2006 in “Journal of Cutaneous Pathology” P63 is a marker for epidermal stem cells in rats.
4 citations
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August 2005 in “Archives of Dermatological Research” Higher p63 and CD34 levels found in specific scalp areas may affect hair loss progression.
