P63: A Crucial Player In Epithelial Stemness Regulation

October 2023 in “ Oncogene ”

Yanan Li, Sara Giovannini, Tingting Wang, Jiankai Fang, Peishan Li, Changshun Shao, Ying Wang, Massimiliano Agostini, Pierluigi Bove, Alessandro Mauriello, Giuseppe Novelli, Mauro Piacentini, Valentina Rovella, Manuel Scimeca, Giuseppe Sica, Qiang Sun, Giuseppe Tisone, Yufang Shi, Eleonora Candi, Gerry Melino, Francesca Bernassola

Studysummary In this review, the researchers detailed how the p63 transcription factor influences epithelial stem cell activities such as self-renewal, differentiation, and proliferation, highlighting the role of TAp63 and ΔNp63 isoforms in both normal tissue development and cancer pathogenesis.

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research Plasticity of Epithelial Cells During Skin Wound Healing

31 citations , November 2022 in “Cold Spring Harbor Perspectives in Biology”

This review explores how epithelial cells from various niches in the skin respond and adapt during acute wound repair, highlighting the role of cellular plasticity in reepithelialization and restoring the skin's barrier function.

P63 Targeted Deletion Under the FOXN1 Promoter Disrupts Pre- and Post-Natal Thymus Development, Function, and Maintenance, and Induces Severe Hair Loss

research P63 Targeted Deletion Under the FOXN1 Promoter Disrupts Pre- and Post-Natal Thymus Development, Function, and Maintenance, and Induces Severe Hair Loss

5 citations , January 2022 in “PloS one”

This study found that lineage-restricted loss of p63 in murine thymic epithelial cells resulted in severe thymic hypoplasia and absence of hair follicles, indicating p63's critical role in thymic and hair follicle development.

research Mechanism of TAp73 Inhibition by ΔNp63 and Structural Basis of p63/p73 Hetero-Tetramerization

29 citations , October 2016 in “Cell death and differentiation”

This study found that in squamous cell carcinomas, the inhibition of the tumor-suppressor function of TAp73β by ΔNp63α occurs through promoter squelching, not direct protein interaction.

research Interleukin 6 and STAT3 Regulate p63 Isoform Expression in Keratinocytes During Regeneration

11 citations , November 2015 in “Experimental Dermatology”

This study reported that IL-6/STAT3 signaling influences p63 isoform expression in keratinocytes and is involved in wound-induced hair follicle neogenesis, highlighting the interplay between immune and developmental pathways.

research Plasticity of Epithelial Stem Cells in Tissue Regeneration

479 citations , June 2014 in “Science”

This review discusses the plasticity of epithelial stem cells in regenerative contexts and reports no new research findings; the authors highlight potential implications for regenerative medicine and cancer.

research P63 Regulates Satb1 to Control Tissue-Specific Chromatin Remodeling During Development of the Epidermis

166 citations , September 2011 in “The Journal of Cell Biology”

This study found that the p63 transcription factor plays a role in epidermal morphogenesis by regulating Satb1 expression, impacting chromatin architecture and gene expression in epidermal progenitor cells.

research P63 Expression Pattern During Rat Epidermis Morphogenesis and the Role of P63 as a Marker for Epidermal Stem Cells

16 citations , September 2006 in “Journal of Cutaneous Pathology”

This study found that the p63 transcription factor is expressed during rat epidermal development and may serve as a specific marker for keratinocyte progenitor cells.

research Expression of Beta-Catenin, p63, and CD34 in Hair Follicles During the Course of Androgenetic Alopecia

4 citations , August 2005 in “Archives of Dermatological Research”

This study detected higher expression of p63 in occipital scalp areas compared to frontal areas, with minimal changes in beta-catenin expression and a novel finding of CD34 positive cells in hair follicles' outer root sheath.