Programmable Artificial Skins Achieve Antiscar Healing with Multiple Appendage Regeneration

October 2024 in “ Advanced Materials ”

Mingchen Xiong, Xinling Yang, Ziwei Shi, Jiangbing Xiang, Huanhuan Gao, Shuaifei Ji, Yingying Li, Wei Pi, Huating Chen, Hongliang Zhang, Mengyang Wang, Yan Li, Yiyue Hong, Dongsheng Liu, Xiaobing Fu, Yuanchen Dong, Xiaoyan Sun

regeneration-directing artificial skin RDAS hydrogels tissue fibrosis scarless wound repair wound fibroblasts in situ regeneration hair follicles sebaceous glands sweat glands antiscarring therapeutic strategy regenerative wound healing artificial skin scarless healing wound healing hair regrowth skin regeneration

Studysummary This study reports that a new artificial skin system using multi-layered hydrogels can promote scarless wound healing and regenerate appendages like hair follicles without cell transplantation.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

The study introduces a novel regeneration-directing artificial skin (RDAS) system designed to enhance skin rehabilitation by preventing disfiguring scars and promoting the regeneration of functional appendages. This system utilizes multi-layered hydrogels that mimic natural skin matrices and employs programmable DNA components to guide the regenerative process without the need for exogenous cell transplantation. The RDAS effectively minimizes tissue fibrosis, enabling rapid scarless wound repair and the regeneration of hair follicles, sebaceous glands, and sweat glands. This cell-free antiscarring therapeutic strategy shows promise for future clinical applications and burn rehabilitation.

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This study found that C57BL/6 mice and Sprague–Dawley rats show distinct distributions of eccrine sweat glands and hair follicles in their volar skin, suggesting these models should be selected according to research focus on skin appendages.

research Multifunctional DNA Hydrogels with Hydrocolloid-Cotton Structure for Regeneration of Diabetic Infectious Wounds

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This study found multipotent progenitors in sweat ducts that become unipotent after sweat gland development, highlighting distinct regenerative capabilities in adult glandular skin stem cell populations.