Multifunctional DNA Hydrogels with Hydrocolloid-Cotton Structure for Regeneration of Diabetic Infectious Wounds

The document describes the development of a multifunctional DNA hydrogel designed for the treatment of diabetic infectious wounds. This hydrogel is created by grafting DNA units with polyethyleneimine dynamic cross-linking and incorporating black phosphorus quantum dots for heating functionality. It exhibits several beneficial properties, including high exudate absorption, adjustable heating, mechanical strength, self-healing, writability, tissue adhesion, and antibacterial effects. Additionally, the hydrogel contains procyanidin B2, which provides antioxidant benefits and helps in scavenging free radicals. The DNA hydrogel dressing not only promotes the transformation of pro-inflammatory macrophages to a repairing phenotype but also activates neurons for skin nerve regeneration and angiogenesis. It also recruits myeloid cells to enhance the adaptive immune response. Remarkably, the dressing aids in tissue regeneration, which includes the regeneration of hair follicles and hair, offering a promising method for managing tissue regeneration in clinical settings.