Adipose Stem Cells From Type 2 Diabetic Mice Exhibit Therapeutic Potential In Wound Healing

In the study by Sun et al., adipose tissue-derived mesenchymal stem cells (ASCs) from type 2 diabetic (T2D) mice were evaluated for their wound healing capabilities. The T2D ASCs displayed similar cellular markers to those from non-diabetic control mice but secreted lower levels of key growth factors such as HGF, VEGF, and TGF-ß. Despite this, T2D ASCs were able to promote wound healing in T2D mice, albeit slightly less effectively than control ASCs, as evidenced by reduced re-epithelialization, cutaneous appendage regeneration, and collagen III deposition. However, they were comparable to control ASCs in promoting skin fibroblast proliferation and migration in vitro by reducing inflammation and macrophage infiltration. The study concluded that T2D ASCs retain therapeutic effects for wound healing, suggesting their potential for autologous stem cell therapy in diabetic patients. The study used 12 mice in each treatment group for in vivo experiments and at least 3 mice per group for in vitro tests.