Activating an Adaptive Immune Response from a Hydrogel Scaffold Imparts Regenerative Wound Healing

    November 2020 in “ Nature Materials ”
    Donald R. Griffin, Maani M. Archang, Chen‐Hsiang Kuan, Westbrook M. Weaver, Jason S. Weinstein, An-Chieh Feng, Amber Ruccia, Elias Sideris, Vasileios Ragkousis, Jaekyung Koh, Maksim V. Plikus, Dino Di Carlo, Tatiana Segura, Philip O. Scumpia
    TLDR Hydrogel scaffolds can help wounds heal better and grow hair.
    The study demonstrated that D-MAP hydrogel scaffolds activated an adaptive immune response, leading to regenerative wound healing and hair follicle neogenesis in mouse models. D-MAP-treated wounds showed significant recruitment of immune cells, enhanced immune activation, and increased hydrogel degradation, resulting in improved tissue regeneration, including increased tensile strength and hair growth. The presence of D-peptides elicited a T cell-dependent antibody response, crucial for skin regeneration and hair formation, unlike the milder response from L-MAP hydrogels. The findings highlighted the potential of using adaptive immune activation through biomaterials for effective tissue regeneration.
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