Activating an Adaptive Immune Response from a Hydrogel Scaffold Imparts Regenerative Wound Healing

    November 2020 in “ Nature Materials ”
    Donald R. Griffin, Maani M. Archang, Chen‐Hsiang Kuan … Philip O. Scumpia
    Studysummary This study found that D-peptide crosslinked MAP hydrogel accelerated material degradation in vivo but significantly enhanced skin regeneration, suggesting an adaptive immune response can drive regenerative healing even with rapid scaffold breakdown.
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    Research cited in this study 7

    1. Single-Cell Analysis Reveals Fibroblast Heterogeneity and Myeloid-Derived Adipocyte Progenitors in Murine Skin Wounds Nature Communications · 2019
    2. Hedgehog Stimulates Hair Follicle Neogenesis by Creating Inductive Dermis During Murine Skin Wound Healing Nature Communications · 2018
    3. Wound Regeneration Deficit in Rats Correlates with Low Morphogenetic Potential and Distinct Transcriptome Profile of Epidermis Journal of Investigative Dermatology · 2018
    4. Regeneration of Fat Cells from Myofibroblasts During Wound Healing Science · 2017
    5. dsRNA Released by Tissue Damage Activates TLR3 to Drive Skin Regeneration Cell Stem Cell · 2015
    6. Skin Shedding and Tissue Regeneration in African Spiny Mice (Acomys) Nature · 2012
    7. Wnt-Dependent De Novo Hair Follicle Regeneration in Adult Mouse Skin After Wounding Nature · 2007