Blank Spots in the Map of Human Skin: The Challenge for Xenotransplantation

    August 2023 in “ International Journal of Molecular Sciences ”
    Olga L. Cherkashina, E. I. Morgun, A. Rippa … Ekaterina P. Kalabusheva
    Studysummary This review discusses the use of human-to-mouse xenografting to study human skin processes in vivo, highlighting its importance for understanding skin regeneration and pathology while identifying knowledge gaps and challenges in applying these findings to human skin.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on mdpi.com →
    Discuss this study in the Community →

    Research cited in this study 34

    1. A Kaleidoscope of Keratin Gene Expression and the Mosaic of Its Regulatory Mechanisms International journal of molecular sciences · 2023
    2. Involvement of ILC1-Like Innate Lymphocytes in Human Autoimmunity: Lessons from Alopecia Areata eLife · 2023
    3. Wound-Induced Hair Neogenesis Model Journal of Investigative Dermatology · 2022
    4. Morphogenesis, Growth Cycle, and Molecular Regulation of Hair Follicles Frontiers in Cell and Developmental Biology · 2022
    5. The Influence of CD26+ and CD26− Fibroblasts on the Regeneration of Human Dermo-Epidermal Skin Substitutes Scientific Reports · 2022
    6. Emerging Role of Dermal White Adipose Tissue in Modulating Hair Follicle Development During Aging Frontiers in Cell and Developmental Biology · 2021
    7. Dermal Adipose Tissue Secretes HGF to Promote Human Hair Growth and Pigmentation Journal of Investigative Dermatology · 2021
    8. Epidermal Stem Cells in Hair Follicle Cycling and Skin Regeneration: A View From the Perspective of Inflammation Frontiers in Cell and Developmental Biology · 2020
    9. Distinct Regulatory Programs Control the Latent Regenerative Potential of Dermal Fibroblasts During Wound Healing Cell stem cell · 2020
    10. Dermal Adipocyte Lipolysis and Myofibroblast Conversion Are Required for Efficient Skin Repair Cell Stem Cell · 2020
    11. Immune Modulation of Hair Follicle Regeneration npj Regenerative Medicine · 2020
    12. Functional Complexity of Hair Follicle Stem Cell Niche and Therapeutic Targeting of Niche Dysfunction for Hair Regeneration Journal of Biomedical Science · 2020
    13. Dermal Adipose Tissue Has High Plasticity And Undergoes Reversible Dedifferentiation In Mice Journal of Clinical Investigation · 2019
    14. Regeneration of Dermis: Scarring and Cells Involved Cells · 2019
    15. Single-Cell Transcriptomics of Traced Epidermal and Hair Follicle Stem Cells Reveals Rapid Adaptations During Wound Healing Cell Reports · 2018
    16. iNKT Cells Ameliorate Human Autoimmunity: Lessons from Alopecia Areata Journal of autoimmunity · 2018
    17. SFRP2/DPP4 and FMO1/LSP1 Define Major Fibroblast Populations in Human Skin Journal of Investigative Dermatology · 2018
    18. Spatial and Single-Cell Transcriptional Profiling Identifies Functionally Distinct Human Dermal Fibroblast Subpopulations Journal of Investigative Dermatology · 2018
    19. Skin Wound Healing in Humans and Mice: Challenges in Translational Research Journal of Dermatological Science · 2017
    20. Regeneration of Fat Cells from Myofibroblasts During Wound Healing Science · 2017
    21. Pharmacologic Inhibition of JAK-STAT Signaling Promotes Hair Growth Science Advances · 2015
    22. A Guide to Studying Human Hair Follicle Cycling In Vivo Journal of Investigative Dermatology · 2015
    23. Principles and Mechanisms of Regeneration in the Mouse Model for Wound-Induced Hair Follicle Neogenesis Regeneration · 2015
    24. Restorative Effect of Hair Follicular Dermal Cells on Injured Human Hair Follicles in a Mouse Model Experimental Dermatology · 2015
    25. Regenerative Hair Waves in Aging Mice and Extra-Follicular Modulators Follistatin, Dkk1, and Sfrp4 Journal of Investigative Dermatology · 2014
    26. The Human Hair: From Anatomy to Physiology International Journal of Dermatology · 2013
    27. Distinct Fibroblast Lineages Determine Dermal Architecture in Skin Development and Repair Nature · 2013
    28. Microenvironmental Reprogramming by Three-Dimensional Culture Enables Dermal Papilla Cells to Induce De Novo Human Hair-Follicle Growth Proceedings of the National Academy of Sciences of the United States of America · 2013
    29. Fgf9 From Dermal γδ T Cells Induces Hair Follicle Neogenesis After Wounding Nature Medicine · 2013
    30. A Nude Mouse Model of Hypertrophic Scar Shows Morphologic and Histologic Characteristics of Human Hypertrophic Scar Wound repair and regeneration · 2012
    31. Autoimmune Disease Induction in a Healthy Human Organ: A Humanized Mouse Model of Alopecia Areata Journal of Investigative Dermatology · 2012
    32. Adipocyte Lineage Cells Contribute to the Skin Stem Cell Niche to Drive Hair Cycling Cell · 2011
    33. Histologic and Cell Kinetic Studies of Hair Loss and Subsequent Recovery Process of Human Scalp Hair Follicles Grafted onto Severe Combined Immunodeficient Mice Journal of Investigative Dermatology · 2000
    34. Failure of Passive Transfer of Serum From Patients With Alopecia Areata and Alopecia Universalis to Inhibit Hair Growth in Transplants of Human Scalp Skin Grafted Onto Nude Mice British Journal of Dermatology · 1992

    Related research 2

    1. Blank Spots in the Map of Human Skin: The Challenge for Xenotransplantation International Journal of Molecular Sciences · 2023
    2. Keratin 79 Identifies a Novel Population of Migratory Epithelial Cells That Initiates Hair Canal Morphogenesis and Regeneration Journal of Cell Science · 2013