TLDR CD26+ fibroblasts improve skin healing and integration better than CD26− fibroblasts.
The study investigated the role of CD26+ and CD26− fibroblasts in the regeneration of human dermo-epidermal skin substitutes using an in vivo model on immune-incompetent rats. It found that CD26+ fibroblasts were more active in producing extracellular matrix components, such as fibronectin and collagen, and facilitated faster ingrowth of blood capillaries, which are crucial for wound healing and tissue regeneration. CD26+ fibroblasts significantly enhanced epidermal stratification, dermal remodeling, and vascularization compared to CD26− fibroblasts. The study concluded that CD26+ fibroblasts play a crucial role in improving the structural and functional integration of skin substitutes, suggesting their potential in enhancing wound healing and tissue engineering applications.
225 citations
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April 2018 in “Journal of Investigative Dermatology” Two main types of fibroblasts with unique functions and additional subtypes were identified in human skin.
418 citations
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January 2018 in “Journal of Investigative Dermatology” Researchers found four distinct fibroblast types in human skin, which could help in treating wounds and fibrotic diseases.
115 citations
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February 2016 in “Nature Communications” Epidermal β-catenin activation changes the dermis by signaling different fibroblast types.
87 citations
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January 2016 in “Development” Blocking β-catenin in skin cells improves hair growth during wound healing.
1235 citations
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December 2013 in “Nature” Two fibroblast types shape skin structure and repair differently.
120 citations
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August 2008 in “The journal of investigative dermatology/Journal of investigative dermatology” Cytokeratin 19 and cytokeratin 15 are key markers for monitoring the quality and self-renewing potential of engineered skin.
74 citations
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August 2023 in “Frontiers in Immunology” Fibroblasts are key to wound healing by managing immune cells and forming scar tissue.
33 citations
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February 2024 in “International Journal of Molecular Sciences” Understanding fibroblast issues in diabetic foot ulcers is key to creating better treatments.
132 citations
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June 2016 in “Cell and Tissue Research” The right cells and signals can potentially lead to scarless wound healing, with a mix of natural and external wound healing controllers possibly being the best way to achieve this.
124 citations
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June 2020 in “Cell Stem Cell” Fat cells in the skin help start healing and form important repair cells after injury.
42 citations
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July 2021 in “Frontiers in Cell and Developmental Biology” Oral mucosa heals with minimal scarring, offering insights for scarless wound healing.
